Pharmacology and Biochemistry Department
Recently Published Manuscripts in International and Local Journals and Conferences
2018 - 2020
| # | Publisher | Author | Title |
|---|---|---|---|
| 1 | Chemico-biological interactions | Khaleel, Sahar A; Raslan, Nahed A; Alzokaky, Amany A; Ewees, Mohamed G; Ashour, Ahmed A; Abdel-Hamied, Hala E; Abd-Allah, Adel R; | Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation |
| 2 | Basic & Clinical Pharmacology & Toxicology | Alzokaky,Amany Abdel‐mageed; Abdelkader, Eman M; El‐Dessouki, Ahmed M; Khaleel, Sahar A; Raslan, Nahed A; | C‐phycocyanin protects against ethanol‐induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF‐κB pathway |
| 3 | Op Acc J Bio Sci & Res | Amany, A Alzokaky; | Targeting the proline-rich tyrosine kinase 2/Mitochondrial calcium uniporter pathway, ruthenium red, and nimodipine alone and in combination evoked neuroprotective effect in experimentally induced brain stroke in rats |
| 4 | Life sciences | Helal, Manar G; Megahed, Nermeen A; Abd Elhameed, Ahmed G; | Saxagliptin mitigates airway inflammation in a mouse model of acute asthma via modulation of NF-kB and TLR4 |
| 5 | Chemico-Biological Interactions | RR Abdеlaziz, M kh Еlmahdy, GM Suddеk | Flavocoxid attenuates airway inflammation in ovalbumin-induced mouse asthma model |
| 6 | International Immunopharmacology | MK ElMahdy, MG Helal, TM Ebrahim | Potential anti-inflammatory effect of dapagliflozin in HCHF diet-induced fatty liver degeneration through inhibition of TNF-α, IL-1β, and IL-18 in rat liver |
| 7 | Journal of Neuroimmunology | MA Abdel-Dayem, ME Shaker, NM Gameil | Impact of interferon β-1b, interferon β-1a and fingolimod therapies on serum interleukins-22, 32α and 34 concentrations in patients with relapsing-remitting multiple sclerosis |
| 8 | Records of Pharmaceutical and Biomedical Sciences 3 (1), 11-16 | Model S Antar, MF El-Azab, R Hazem, M Saleh | Investigating Pirfenidone and Vitamin D for Targeting Cardiac and Renal Fibrotic Pathways in Experimentally-Induced Animal |
| 9 | Pharmaceuticals 13 (11), 348 | MA Saleh, SA Antar, RM Hazem, MF El-Azab | Pirfenidone and vitamin D ameliorate cardiac fibrosis induced by doxorubicin in Ehrlich ascites carcinoma bearing mice: modulation of monocyte chemoattractant protein-1 and Jun … |
| 10 | Experimental Biology and Medicine 244(7):545-553. | El-Ashmawy N E, Khedr E G, Shamloula M M, and Kamel M M | Evaluation of the antirheumatic effects of isoflavone-free soy protein isolate and etanercept in rats with adjuvant-induced arthritis |
| 11 | Molecular Biology Reports 45(5):1421-1444. | Elshazli R M, Salman D O, Kamel M M, Toraih E A, and Fawzy M S | Genetic polymorphisms of IL-17A rs2275913, rs3748067 and IL-17F rs763780 in gastric cancer risk: evidence from 8124 cases and 9873 controls. |
| 12 | Nahla E El-Ashmawy, Eman G Khedr, Awad M ElAbd, Amir O Hamouda | Association Between Soluble Urokinase Plasminogen Activator Receptor And Interleukin 6 In The Diagnosis Of Coronary Artery Disease Patients | |
| 13 | Tumor Biology, 4(42): 1010430000000000 | Yousef, Eman H; El-Mesery, Mohamed E; Habeeb, Maha R; Eissa, Laila A; | Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma |
Published Manuscripts in International and Local Journals and Conferences
2021 –2022
| # | Publisher | Author | Title |
|---|---|---|---|
| 1 | Azhar International Journal of Pharmaceutical and Medical Sciences | Fouad, Lamiaa; Alzokaky, Amany; Abdelbaky, Nayira; Ahmed, Kawkab; | Telmisartan inhibits the non-canonical TGF-β/JAK2/STAT3 signaling pathway and prevents carbon tetrachloride-induced liver fibrosis in rats |
| 2 | Azhar International Journal of Pharmaceutical and Medical Sciences | Ahmed, Marwa A; Alzokaky, Amany A; Raslan, Nahed A; Abdelbaky, Nayira A; | Comparative study on the influence of L carnitine and/or fenofibrate against streptozotocin induced diabetic nephropathy: role of TGF-β1/Smad Signaling Pathway. |
| 3 | Journal of Advanced Pharmacy Research | Abd Elhameed, Ahmed; Suliman, Sara; Elsbaey, Marwa; Elnaggar, Mai; Badria, Farid; | Mangifera indica Leaves Extracts Mitigate Experimentally Induced Oxidative Stress and Iron-Overload via Iron Chelation and Modulation of HO-1, Nrf2, and MMP-9 |
| 4 | Pharmaceuticals | Mazyed, Eman A; Helal, Doaa A; Elkhoudary, Mahmoud M; Abd Elhameed, Ahmed G; Yasser, Mohamed; | Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate |
| 5 | Environmental Science and Pollution Research | Helal, Manar G; Abd Elhameed, Ahmed G; | Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk |
| 6 | Environmental Science and Pollution Research | Abd Elhameed, Ahmed G; | Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway |
| 7 | Journal of Advanced Pharmacy Research | Helal, Manar; Shawky, Mohamed; Elhusseiny, Shady; Abd Elhameed, Ahmed; | Lactoferrin Ameliorates Azithromycin-induced Cardiac Injury: Insight into Oxidative Stress/TLR4/NF-κB Pathway |
| 8 | Environmental Toxicology and Pharmacology | Abd Elhameed, Ahmed G; Helal, Manar G; Said, Eman; Salem, Hatem A; | Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling |
| 9 | Pharmaceuticals | Mourad, Ahmed AE; Khodir, Ahmed E; Saber, Sameh; Mourad, Mai AE; | Novel potent and selective DPP-4 inhibitors: design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids |
| 10 | International Immunopharmacology | El-Baz, Ahmed M; Shata, Ahmed; Hassan, Hanan M; El-Sokkary, Mohamed MA; Khodir, Ahmed E; | The therapeutic role of Lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress |
| 11 | Pharmaceuticals ,MDPI | Saber, Sameh; Abd El-Fattah, Eslam E; Yahya, Galal; Gobba, Naglaa A; Maghmomeh, Abdalkareem Omar; Khodir, Ahmed E; Mourad, Ahmed AE; Saad, Ahmed S; Mohammed, Hager G; Nouh, Nehal A; | A novel combination therapy using rosuvastatin and lactobacillus combats dextran sodium sulfate-induced colitis in high-fat diet-fed rats by targeting the TXNIP/NLRP3 interaction and influencing gut microbiome composition |
| 12 | Environmental Toxicology and Pharmacology | El-Sherbiny, Mohamed; Eisa, Nada H; El-Magd, Nada F Abo; Elsherbiny, Nehal M; Said, Eman; Khodir, Ahmed E; | Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into tlr4/nf-kb/caspase signalling modulation |
| 13 | International Immunopharmacology | Antar, Samar A; ElMahdy, Mohamed Kh; Khodir, Ahmed E; | A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1/JNK1 pathway |
| 14 | RSC advances | Hamed, Mohammed IA; Darwish, Khaled M; Soltane, Raya; Chrouda, Amani; Mostafa, Ahmed; Shama, Noura M Abo; Elhady, Sameh S; Abulkhair, Hamada S; Khodir, Ahmed E; Elmaaty, Ayman Abo; | β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization |
| 15 | Azhar International Journal of Pharmaceutical and Medical Sciences | Fouad, Lamiaa; Alzokaky, Amany; Abdelbaky, Nayira; Ahmed, Kawkab; | Telmisartan inhibits the non-canonical TGF-β/JAK2/STAT3 signaling pathway and prevents carbon tetrachloride-induced liver fibrosis in rats |
| 16 | Azhar International Journal of Pharmaceutical and Medical Sciences | Ahmed, Marwa A; Alzokaky, Amany A; Raslan, Nahed A; Abdelbaky, Nayira A; | Comparative study on the influence of L carnitine and/or fenofibrate against streptozotocin induced diabetic nephropathy: role of TGF-β1/Smad Signaling Pathway. |
| 17 | International Immunopharmacology | SA Antar, MK ElMahdy, AE Khodir | A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1/JNK1 pathway |
| 18 | Biomedicines | MK ElMahdy, SA Antar, EK Elmahallawy, W Abdo, HHA Hijazy, ... | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB … |
| 19 | Life Sciences | MK ElMahdy, MO Zaki, AA Al-Karmalawy, W Abdo, SM Alnasser, SA Antar | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases … |
| 20 | Autoimmunity | MK Еlmahdy, RR Abdelaziz, HS Elmahdi, GM Suddеk | Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study |
| 21 | Biocell 45 (6), 1561 | SG El-Sawah, F Althobaiti, A Aldhahrani, E Fayad, MA Abdel-Dayem, ... | Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues |
| 22 | Journal of Food Science and Nutrition Research 4 (3), 227-239 | AM El-Mowafy, MA Abdel-Dayem | Novel protection by omega-3-FAs against strychnine-induced tonic-convulsion in mice: synergy with carbamazepine |
| 23 | Life sciences | SA Antar, W Abdo, RS Taha, AE Farage, LE El-Moselhy, ME Amer | Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats , ... |
| 24 | Life Sciences | RM Hazem, SA Antar, YK Nafea, AA Al-Karmalawy, MA Saleh, | Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor ... |
| 25 | Life Sciences 303, 120691 11 | MF El-Azab, AA Al-Karmalawy, SA Antar, PA Hanna, KM Tawfik | A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways |
| 26 | Biomedicines 10 (1), 40 9 | MK ElMahdy, SA Antar, EK Elmahallawy, W Abdo, HHA Hijazy, ... | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB … |
| 27 | Pharmaceutical Sciences 28 (4), 525-540 | S Antar, AA Al-Karmalawy, A Mourad, M Mourad, M Elbadry, S Saber | Protective effects of mirazid on gentamicin-induced nephrotoxicity in rats through antioxidant, anti-inflammatory, JNK1/iNOS, and apoptotic pathways; novel mechanistic insights , ... |
| 28 | Journal of Medicinal Chemistry | AA Al-Karmalawy, MS Nafie, MA Shaldam, AA Elmaaty, SA Antar, . | Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo |
| 29 | Life Sciences 311, 121184 | MK ElMahdy, MO Zaki, AA Al-Karmalawy, W Abdo, SM Alnasser, SA Antar | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases … |
| 30 | Environmental Science and Pollution Research 29 (19), 28194-28207 | SA Antar, MA El-Gammal, RM Hazem, YM Moustafa | Etanercept Mitigates Cadmium Chloride-induced Testicular Damage in Rats" An Insight into Autophagy, Apoptosis, Oxidative Stress and Inflammation" |
| 31 | Environmental Science and Pollution Research, 1-10 | ME Youssef, MF El-Azab, MA Abdel-Dayem, G Yahya, IS Alanazi, S Saber | Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats |
| 32 | Clinical Nutrition Open Science 42, 14-26 | AM El-Mowafy, AA Abdel-Aziz, MA Abdel-Dayem | Novel protection by Omega-3-FAs (DHA or EPA) against carbamazepine's liver-injury: differential suppression of oxidative-stress and inflammatory markers, and the influence on … |
| 33 | Biocell 46 (3), 745 | SG El-Sawah, F Althobaiti, HM Rashwan, A Aldhahrani, MA Abdel-Dayem, ... | Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreatic β-cells auto-immunity and apoptosis in rats with T1DM induced model |
| 34 | Biocell 46 (3), 745 | Mennatallah O; Zaki, Elshe Mohamed; Azab, Samar S;rbiny, Doaa A; Salama, | Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy |
| 35 | Life Sciences, 279:119673. | Elnagar G M, Elseweidy M M, Mahmoud Y K, Elkomy N M, Althafar Z M, Alnomasy S F, Al-Gabri N A, and Shawky M | 10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats. |
| 36 | Current Issues in Molecular Biology 43(3):2199-2209. | Salahuddin M M, Omran G A, Helmy M W, and Houssen M E | Effect of regorafenib on P2X7 receptor expression and different oncogenic signaling pathways in a human breast cancer cell line: a potential of new insight of the antitumor effects of regorafenib. |
| 37 | Journal of Advanced Pharmacy Research, 2021, 5 (2), 273-284 | Manar G. Helal, Mohamed Shawky, Shady Elhusseiny, Ahmed G. Abd Elhameed | Lactoferrin Ameliorates Azithromycin-induced Cardiac Injury: Insight into Oxidative Stress/TLR4 /NF-κB Pathway |
Published Manuscripts in International and Local Journals and Conferences
2022-2023
| # | Publisher | Author | Title |
|---|---|---|---|
| 1 | Biomedicine & Pharmacotherapy | Gendy, Abdallah M; Elnagar, Mohamed R; Allam, Mona M; Mousa, Mohamed R; Khodir, Ahmed E; El-Haddad, Alaadin E; Elnahas, Osama S; Fayez, Sahar M; El-Mancy, Shereen S; | Berberine-loaded nanostructured lipid carriers mitigate warm hepatic ischemia/reperfusion-induced lesion through modulation of HMGB1/TLR4/NF-κB signaling and autophagy |
| 2 | South African Journal of Botany | Zaki, Ahmed A; Al‐Karmalawy, Ahmed A; Khodir, Ahmed E; El-Amier, Yasser A; Ashour, Ahmed; | Isolation of cytotoxic active compounds from Reichardia tingitana with investigation of apoptosis mechanistic induction: In silico, in vitro, and SAR studies |
| 3 | Biomedicines | ElMahdy, Mohamed Kh; Antar, Samar A; Elmahallawy, Ehab Kotb; Abdo, Walied; Hijazy, Hayfa Hussin Ali; Albrakati, Ashraf; Khodir, Ahmed E; | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB)/Interleukin-18 (IL-18) |
| 4 | Redox Report | El-Far, Yousra M; Khodir, Ahmed E; Emarah, Ziad A; Ebrahim, Mohamed A; Al-Gayyar, Mohammed MH; | Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide |
| 5 | Research Journal of Pharmacy and Technology (RJPT) | Saber, Sameh; Khodir, Ahmed E; Maghmomeh, Abdalkareem Omar; Nouh, Nehal A; El-Baz, Ahmed M; | COVID-19 Pandemic: current Challenges and future Perspectives |
| 6 | Pharmaceutical Sciences | Antar, Samar A; Al-Karmalawy, Ahmed A; Mourad, Ahmed AE; Mourad, Magda; MennaallahElbadry, Sameh Saber; Khodir, Ahmed E; | Protective Effects of Mirazid on Gentamicin-induced Nephrotoxicity in Rats through Antioxidant, Anti-inflammatory, JNK1/iNOS, and Apoptotic Pathways; Novel Mechanistic Insights |
| 7 | Biomedicine & Pharmacotherapy | Saber, Sameh; Nasr, Mohamed; Kaddah, Mohamed MY; Mostafa-Hedeab, Gomaa; Cavalu, Simona; Mourad, Ahmed AE; Gaafar, Ahmed Gaafar Ahmed; Zaghlool, Sameh S; Saleh, Safaa; Hafez, Mohamed M; | Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: A new challenge for unmet therapeutic needs |
| 8 | Environmental Toxicology and Pharmacology | Eisa, Nada H; Said, Eman; Khodir, Ahmed E; Sabry, Dina; Ebrahim, Hasnaa Ali; Elsherbini, Dalia Mahmoud Abdelmonem; Altemani, Reem; Alnasser, Dania Mohammed; Elsherbiny, Nehal M; El-Sherbiny, Mohamed; | Effect of Diacerein on HOTAIR/IL-6/STAT3, Wnt/β-Catenin and TLR-4/NF-κB/TNF-α axes in colon carcinogenesis |
| 9 | European Journal of Pharmacology | Khalaf, Eman M; Hassan, Hanan M; El-Baz, Ahmed M; Shata, Ahmed; Khodir, Ahmed E; Yousef, Mahmoud E; Elgharabawy, Rehab Mohamed; Nouh, Nehal A; Saleh, Safaa; Bin-Meferij, Mashael M; | A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: Role of oxidative stress, gut microbiota, and PPARγ activation |
| 10 | Journal of Enzyme Inhibition and Medicinal Chemistry | Mourad, Mai AE; Abo Elmaaty, Ayman; Zaki, Islam; Mourad, Ahmed AE; Hofni, Amal; Khodir, Ahmed E; Aboubakr, Esam M; Elkamhawy, Ahmed; Roh, Eun Joo; Al-Karmalawy, Ahmed A; | Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho [2′, 3′: 4, 5] thiazolo [3, 2-a] pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity |
| 11 | Cureus | Aljohani, Heba; Khodier, Ahmed E; Al-Gayyar, Mohammed M; | Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway |
| 12 | Inflammation" Environmental Science and Pollution Research 29 (19), 28194-28207 | SA Antar, MA El-Gammal, RM Hazem, YM Moustafa | Etanercept Mitigates Cadmium Chloride-induced Testicular Damage in Rats" An Insight into Autophagy, Apoptosis, Oxidative Stress and |
| 13 | Biomedical Sciences 6 (3), 28-33 | MA El Gammal, R Hazem, Y Moustafa | Mechanisms of Cadmium-Induced Testicular Damage |
| 14 | International Journal of Molecular Sciences 24 (4), 4004 | SA Antar, NA Ashour, ME Marawan, AA Al-Karmalawy | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation |
| 15 | Life Sciences 322, 121688 | AE Farage, W Abdo, A Osman, MA Abdel-Kareem, ZH Hakami | Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats |
| 16 | Toxics 11 (3), 273 | SA Antar, M Abd-Elsalam, W Abdo, A Abdeen, M Abdo, L Fericean | Modulatory Role of Autophagy in Metformin Therapeutic Activity toward Doxorubicin-Induced Nephrotoxicity |
| 17 | Life Sciences | ElMahdy, Mohamed Kh; Zaki, Mennatallah O; Al-Karmalawy, Ahmed A; Abdo, Walied; Alnasser, Sulaiman Mohammed; Antar, Samar A; | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways |
| 18 | Inflammopharmacology | Zaki, Mennatallah O; El-Desouky, S; Elsherbiny, Doaa A; Salama, Mohamed; Azab, Samar S; | Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling |
| 19 | Clinical Schizophrenia & Related Psychoses | Zaki, Mennatallah O; El-Sherifi, Saad Shawki; Abou Elmaaty, Ali Ahmed; Zakaria, Amr Y; Zidan, Abdelrheem M; Mahmoud, Abdullrahman M; Ali, Omar Sh; …… Marwa A Abdel-Dayem | Evaluation of andbeta; Amyloids and Tau Protein Biomarkers for Alzheimerandrsquo; s Disease in Serum of Alzheimer Patients |
| 20 | European Review for Medical and Pharmacological Sciences 26(23):8644-8659 | Hamouda A, Abdel-Hamed A, Abo-Elmatty D, Khedr N, and Ghattas M | Pentoxifylline and its association with kaempferol improve NASH-associated manifestation in mice through anti-apoptotic, anti-necroptotic, antioxidant, and anti-inflammatory mechanisms. |
| 21 | Journal of Medicinal and Chemical Sciences 6(5):250-265 | Maivel H. Ghattas Asmaa R. Abdel-Hamed, Amir O. Hamouda, Dina M. Abo-elmatty, Naglaa F. Khedr | Role of Kaempferol Combined with Pioglitazone in the Alleviation of Inflammation and Modulation of Necroptosis and Apoptosis Pathways in NASH-induced Mice . |
| 22 | international Journal of Molecular Sciences 23(3):1384 | Elnagar G M, Elseweidy M M, Mahmoud Y K, Elkomy N M, Althafar Z M, Alnomasy S F, Al-Gabri N A, and Shawky M | 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition. |
| 23 | Cells 11(24):4128. | Elnagar G M, Elseweidy M M, Mahmoud Y K, Elkomy N M, Althafar Z M, Alnomasy S F, Al-Gabri N A, and Shawky M | Relative Importance of Different Elements of Mitochondrial Oxidative Phosphorylation in Maintaining the Barrier Integrity of Retinal Endothelial Cells: Implications for Vascular-Associated Retinal Diseases. , ... |
| 24 | International Journal of Molecular Sciences. 2023;24:4004. | Antar SA, Ashour NA, Marawan ME, Al-Karmalawy AA. | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation. |
Biochemistry Student Projects
2020-2021
| Under the Supervision | Research Project |
|---|---|
| Ass. Prof. Dr.Amany Alzokaky | "Mechanistic Pathways Includedin Pathogenesis of Brain Stroke |
| Ass. Prof. Dr.Amany Alzokaky | Mechanistic Pathways Related to Nephrotoxicity |
| Ass. Prof. Dr. Ahmed Gamal | Hepatocellular Carcinoma ; pathogenesis & Advanced Therapeutic strategie |
| Ass. Prof. Dr. Ahmed Gamal | Advanced Therapeutic strategies in Treatment of Ulcerative Colitis |
| Lecturer of pharmacology Dr. Marwa Ahmed | latrogenic Diseases |
| Lecturer of pharmacology Dr. Marwa Ahmed | Risk Factors and Mortality Rates among Patients with covid - 19 |
| Ass. Prof. Dr. Ahmed Esam | Pharmacological Treatment of covid -19 |
| Ass. Prof. Dr. Ahmed Esam | Anti - inflammatoryeffect of Apitherapyproducts |
| Lecturer of pharmacology Dr. Mohamed khalil El - Mahdy | Covid 19 in high riskchronic diseased patients and pregnant woman : Pathophysiology , available drug treatment and the most suitable protocol regiman in each group |
| Dr. Mohamed Shawky | Cytokines Storm in COVID-19; Pathogenesis and Management |
| Dr. Mohamed Shawky | Lysosomal Storage Diseases. |
Biochemistry Student Projects
2021-2022
| Under the Supervision | Research Project |
|---|---|
| Ass. Prof. Dr. Amany Alzokaky | The role of antioxidants in the Protection from gastric ulcer via NRf2 Pathway |
| Ass. Prof. Dr. Amany Alzokaky | The Protective effect of Natural Antioxidants againstGrastric uicer induced in Rats |
| Ass. Prof. Dr. Ahmed Gamal | Theraputic Advances for Management of kindey injury |
| Ass. Prof. Dr. Ahmed Gamal | The Emerging role of dipeptidyl Peptidase - 4 inhibitors in management of human carcinogenesis |
| Lecturer of pharmacology Dr. Marwa Abd Eldayeem | SGLT2 inhibitors: novel mechanisms of cardiovascular benefits beyond glycaemic control |
| Lecturer of pharmacology Dr. Marwa Ahmed | Iatrogenic Diseases |
| Lecturer of pharmacology Dr. Samar Ahmed Anter | Investigation the effect of Mebeverine on Doxorubicin- Induced kidney damage |
| Ass. Prof. Dr. Ahmed Esam | Curative effect of nifuroxazida on doxorubicin induced nephrotoxicity |
| Ass. Prof. Dr. Ahmed Esam | curative effect of mebeverine on doxorubicin induced Hapatotoxicity in mice |
| Lecturer of pharmacology Dr. Mohamed khalil El - Mahdy | Effect of inhaled unfractionated heparin on airway inflammation in ovalbumin inducedasthma in mice |
| Lecturer of Biochemistry Dr. Mohamed Shawky Assistant lecturer of biochemistry Dr. Muhammed Salahuddin | - Cisplatin induced renal injury. Role of Grape seed extract as potential therapeutic agent. |
| Lecturer of Biochemistry Dr. Mohamed Shawky Assistant lecturer of biochemistry Dr. Maha Kamel | - Cisplatin induced renal injury. Role of Silymarin as potential therapeutic agent. |
Biochemistry Student Projects
2022-2023
| Under the Supervision | Research Project |
|---|---|
| Ass. Prof. Dr. Amany Alzokaky | Empagliflozin ameliorates acute hepaticinjury and nephrotoxicity induced bccL4 in mice |
| Ass. Prof. Dr. Amany Alzokaky | The Possible Protective Effect of Spirulina Maxima on nephrotoxicity and acute liver injury Induced by CC14 in Mice |
| Ass. Prof. Dr.Ahmed Gamal Helal | Cardioprotective and Antioxidant Effect of Vardenafil on Doxorubicin-Induced Cardiomyopathy |
| Ass. Prof. Dr.Ahmed Gamal Helal | Management of Neuropathic Pain |
| Ass. Prof. Dr.Ahmed Esam Khodir | Possible Protective Effect Of Atorvastatin On Cisplatin Inducing Brain Damage In Rats |
| Ass. Prof. Dr.Ahmed Esam Khodir | Possible Protective Effect Of Coenzyme Q 10 On Cisplatin Inducing Brain Damage In Rats |
| Lecturer of pharmacology Dr.Samar Anter | Diabetes mellitus: Symptoms, Classification, and Complications |
| Lecturer of pharmacology Dr.Samar Anter | Fibrosis: from mechanisms to medicines |
| Lecturer of pharmacology Dr. Mohamed Khalil | Diabetic Complications on Cardiovascular System and nervous System : Pathophysiology and Most appropriate Treatment |
| Lecturer of pharmacology Dr. Mohamed Khalil | Effect of Dapagliflozin on bleomycin-induced Iung fibrosis in mice : Prevention and Treatment |
| Lecturer of Biochemistry Dr. Muhammed Salahuddin Assistant lecturer Eman Hamdy Mohamed | Biochemical Effect of Ambroxol and Tadalafil on Methotrexate Induced Liver Injury in Mice |
| Lecturer of Biochemistry Dr. Muhammed Salahuddin Assistant lecturer Eman Hamdy Mohamed | Biochemical Effect of Ambroxol and Tadalafil on Methotrexate Induced kidney Injury in Mice |
Published manuscripts in international and local journals and conferences
2024–2023
| # | Title | Author | journal |
|---|---|---|---|
| 1 | A randomized placebo-controlled, double-blind study to investigate the effect of a high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients, new insights on serum STAT-3 and hepassocin | S.J. Alarfaj, M.M. Bahaa, H.A. Yassin, E. El-Khateeb, F.A. Kotkata, M.A. El-Gammal, | European Review for Medical & Pharmacological Sciences. 2023 |
| 2 | Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7 | Eman H Yousef, Nada F Abo El-Magd, Amal M El Gayar | Life Sciences, -2023 |
| 3 | Norcantharidin potentiates sorafenib antitumor activity in hepatocellular carcinoma rat model through inhibiting IL-6/STAT3 pathway | Eman H Yousef, Nada F Abo El-Magd, Amal M El Gayar | Translational Research-- 2023 |
| 4 | Diosgenin potentiates the anticancer effect of doxorubicin and volasertib via regulating polo-like kinase 1 and triggering apoptosis in hepatocellular carcinoma cells | Eman H Yousef , Mohamed E El-Mesery , Maha R Habeeb , Laila A Eissa | Naunyn-Schmiedeberg's Archives of Pharmacology,2024 |
| 5 | Revealing the association between vitamin D metabolic pathway gene variants and lung cancer risk: a systematic review and meta-analysis | Mohamed I Elsalahaty, Samar Sami Alkafaas, Aya O Bashir, Khaled A El-Tarabily, Mohamed T El-Saadony , Eman H Yousef | Frontiers in genetics- 2024 |
| 6 | Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway | Heba Aljohani,1 Ahmed E Khodier,2 and Mohammed M Al-Gayyar | Cureus. 2023 May; 15(5): e39789. |
| 7 | Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways | Samar A Antar, Ahmed Ashour, Walied Abdo, Ahmed E Khodir, Asmaa E Sherif, Longxin Qiu, Ahmed A Zaki | 11 Jan 2024 |
| 8 | Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives | Osama Mohammed , Sameh Saber b, Mustafa Ahmed Abdel-Reheim ...... Amany A. Alzokaky | Toxicology and Applied Pharmacology Volume 486, May 2024, 116943 |
| 9 | Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice | Amany A. Alzokaky, Ahmed A. Al-Karmalawy , Mohamed A. Saleh, Walied Abdo, ......, Samar A. Antar | Life Sciences Volume 316, 1 March 2023, 121390 |
| 10 | Modulatory Role of Autophagy in Metformin Therapeutic Activity toward Doxorubicin-Induced Nephrotoxicity | SA Antar, M Abd-Elsalam, W Abdo, A Abdeen, M Abdo, L Fericean, ..., A Alzokaky | Toxics 11 (3), 273 |
| 11 | Piracetam mitigates nephrotoxicity induced by cisplatin via the AMPK-mediated PI3K/Akt and MAPK/JNK/ERK signaling pathways | Ahmed M. El-Dessouki, Amany A. Alzokaky, Nahed A Raslan, Samar Ibrahim, Lamiaa A. Salama, Eman H. Yousef | International Immunopharmacology Volume 137, 20 August 2024, 112511 |
| 12 | Mechanistic insight into the hepatoprotective effect of Moringa oleifera Lam leaf extract and telmisartan against carbon tetrachloride-induced liver fibrosis: plausible roles of TGF-β1/SMAD3/SMAD7 and HDAC2/NF-κB/PPARγ pathways | Baky, N.A.A., …, Alzokaky, A.A. | Drug and Chemical Toxicology, 2024 |
| 13 | Association of CTLA-4 rs733618 and rs4553808 Gene Variants with Psoriasis Vulgaris in Egyptian Population | Menna M. Eldawoudy1,4*, Dalia Shaalan2, Maivel H. Ghattas3, Dina M. Abo-Elmatty4, Eman T. Mehanna | Archives of Dermatological Research.2024 |
| 14 | Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study | Khlood M. Aldossary, …, Amir O. Hamouda, Muhammed M. Salahuddin | Front. Pharmacol., 24 May 2024 |
| 15 | Correlation between depression scores and serum NF-ĸB/NLRP3 axis, biotinidase, and HMGB1 after treatment with isotretinoin in patients with acne vulgaris. | Ammena Y. Binsaleh, …, Amir O. Hamouda, Muhammed M. Salahuddin | J Cosmet Dermatol. 2024; 00:1–9. |
| 16 | Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments | Ahmed A. Al-Karmalawy,* Amir O. Hamouda. | J. Med. Chem. 2023 Vol 67/Issue 1 |
| 17 | A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α | Ammena Y. Binsaleh1Amir O. Hamouda7Muhammed M. Salahuddin7 | Front. Med. Volume 11 - 2024 |
| 18 | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation | Samar A. Antar Nada A. Ashour Mohamed E. Marawan Ahmed A. Al-Karmalawy | Int. J. Mol. Sci. 2023, 24(4), 4004; |
| 19 | Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity | Mai AE Mourad, Ayman Abo Elmaaty, Islam Zaki, Ahmed AE Mourad, Amal Hofni, Ahmed E Khodir, Esam M Aboubakr, Ahmed Elkamhawy, Eun Joo Roh, Ahmed A Al-Karmalawy | Journal of Enzyme Inhibition and Medicinal Chemistry 2023 |
| 20 | Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice | Mohamed A Saleh, Samar A Antar, Walied Abdo, Ahmed Ashour, Ahmed A Zaki | Journal of Environmental Science and Pollution Research |
| 21 | Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats | Amira E Farage, Walied Abdo, Amira Osman, Mona A Abdel-Kareem, Zaki H Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S Alanazi, Bader Alsuwayt, Mohammed M Alanazi, Samar A Antar, Emadeldin M Kamel, Ayman M Mahmoud | Journal of Life Sciences |
| 22 | A comprehensive overview of organ inflammatory responses: genesis, possible mechanisms, and mediators of inflammation | Samar A Antar, Ayman M Mahmoud, Walied Abdo, Cherry Gad, Ahmed A Al-Karmalawy | Pharmaceutical Sciences |
| 23 | An Overview of the Mechanisms of Cadmium-induced Toxicity in the Male Reproductive System | Samar A Antar, Aymen Halouani, Cherry Gad, Ahmed Ali Al-Karmalawy | Pharmaceutical Sciences |
| 24 | Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments | Samar A Antar, Nada A Ashour, Marwa Sharaky, Muhammad Khattab, Naira A Ashour, | Biomedicine & Pharmacotherapy |
| 25 | Examining the contribution of Notch signaling to lung disease development | Samar A Antar, Mohamed Kh ElMahdy, Ahmed G Darwish | Naunyn-Schmiedeberg's Archives of Pharmacology |
| 26 | Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice | Samar A Antar, Walied Abdo, Azza I Helal, Maisa Siddiq Abduh, Zaki H Hakami, Mohamed Kh ElMahdy | Life Sciences |
| 27 | Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways | Samar A Antar, Ahmed Ashour, Walied Abdo, Ahmed E Khodir, Asmaa E Sherif, | Arab Journal of Basic and Applied Sciences |
| 28 | Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice | Mahmoud E Youssef, Simona Cavalu, Alexandru Madalin Hasan, Galal Yahya, Marwa A Abd-Eldayem, Sameh Saber | International Journal of Molecular Sciences |
| 29 | Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control | Mahmoud E Youssef, Galal Yahya, Mihaela Simona Popoviciu, Simona Cavalu, Marwa A Abd-Eldayem, Sameh Saber | International Journal of Molecular Sciences |
| 30 | Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat mode | Simona Cavalu, Sameh Saber, Rasha Elmowafy, Nesreen Elsayed Morsy, Samar Ibrahim, Mahmoud Said Ibrahim Abdeldaiem, Mervat Samy, Marwa A Abd-Eldayem, Ahmed Shata, Rehab Mohamed Elgharabaw | Biomedicine & Pharmacotherapy |
| 31 | Association of HOTAIR gene rs920778 (C > T) and rs4759314 (A > G) polymorphism with breast cancer in Egyptian women | Mohammad M Tarabay, Rehab Elmougy, Marwa Ahmed Abdel-Dayem, | Molecular Biology Reports |
| 32 | Promising Experimental Anti-SARS-CoV-2 Agent “SLL-0197800”: The Prospective Universal Inhibitory Properties against the Coming Versions of the Coronavirus | Amgad M Rabie, Marwa A Abdel-Dayem, Mohnad Abdalla | ACS omega |
| 33 | Glycine is Dysregulated in Human Retinal Endothelial Cells and Proliferative Diabetic Retinopathy | Andrew Gregory, Shaimaa Eltanani, Thangal Yumnamcha, Mohamed Shawky | WAYNE STATE UNIVERSITY |
| 34 | Relative Contribution of Different Upper Glycolytic Components in the maintenance of the Retinal Vascular Endothelial Cell Barrier | Nicole Oska, Ahmed Ibrahim, Mohamed Shawky, Diego Galarza Ramirez, | Investigative Ophthalmology & Visual Science |
| 35 | The Warburg effect alters amino acid homeostasis in human retinal endothelial cells: implication for proliferative diabetic retinopathy | Andrew Gregory, Thangal Yumnamcha, Mohamed Shawky, Shaimaa Eltanani | Scientific Reports |
| 36 | Upper glycolytic components contribute differently in controlling retinal vascular endothelial cellular behavior: Implications for endothelial-related retinal diseases | Nicole Oska, Shaimaa Eltanani, Mohamed Shawky, Armaan Naghdi | Plos one |
| 37 | The Roles of Lower Glycolytic Enzymes and Transporters in Regulating the Barrier Integrity and Spreading Behavior of Retinal Endothelial Cells | Nicole Barbara Oska, Shaimaa Eltanani, Mohamed Shawky, Thangal Yumnamcha | Investigative Ophthalmology & Visual Science |
| 38 | Purine and pyrimidine monophosphate vs polyphosphate homeostasis in human retinal endothelial cells | Andrew Gregory, Jenna Hart, Thangal Yumnamcha, Mohamed Shawky | WAYNE STATE UNIVERSITY |
| 39 | The Roles of Lower Glycolytic Enzymes and Transporters in Regulating the Integrity of Retinal Vascular Endothelial Cell Barrier | Nicole Oska, Shaimaa Eltanani, Mohamed Shawky, Thangal Yumnamcha, | WAYNE STATE UNIVERSITY |
| 40 | Lactate/Pyruvate Regulation as a Key Determinant for Maintaining Retinal Pigment Epithelium Barrier Function: Insights from Glycolytic Screening | Armaan Naghdi, Nicole Barbara Oska, Thangal Yumnamcha, Shaimaa Eltanani, Mohamed Shawky, | Investigative Ophthalmology & Visual Science |
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