Medicinal Chemistry Publications – Faculty of Pharmacy

Medicinal Chemistry

Publications

Publications and Year	Name
Insights of different analytical approaches for estimation of budesonide as COVID-19 replication inhibitor in its novel combinations: green assessment with AGREE and GAPI approaches, Mohammed E. A. Hammouda, Amal A. El-Masry, Saadia M. El-Ashry & Dalia R. El-Wasseef, BMC chemistry 17 (1), 1-14‏, 2023 Insights on the in-vitro binding interaction between donepezil and bovine serum albumin ‏, Reem N El Gammal, Heba Elmansi, Ali A El-Emam, Fathalla Belal, Perihan A Elzahhar, Ahmed SF Belal, Mohammed EA Hammouda, BMC chemistry 17 (1), 31‏, 2023 Isocratic ion pair chromatography for estimation of novel combined inhalation therapy that blocks coronavirus replication in chronic asthmatic patients‏, Mohammed EA Hammouda, Yomna A Salem, Saadia M El-Ashry, Mohamed A Abu El-Enin, Scientific Reports 13 (1), 305‏, 2023 Multiple sensitive eco‐friendly analytical approaches for the determination of two fourth‐generation fluoroquinolones: Application to stability study and content uniformity testing‏, Reem N El Gammal, Dalia R El‐Wasseef, Saadia M El‐Ashry, Mohammed EA Hammouda‏, Journal of the Chinese Chemical Society 69 (11), 1924-1936, ‏2022 Exploring the molecular interaction of mebendazole with bovine serum albumin using multi-spectroscopic approaches and molecular docking‏, Reem N El Gammal, Heba Elmansi, Ali A El-Emam, Fathalla Belal, Mohammed EA Hammouda, Scientific Reports 12 (1), 11582‏, 2022 Applying eco‐friendly micellar liquid chromatography for the simultaneous determination of two ternary mixtures utilized for cold treatment using monolithic column‏, Mohamed A Abu El‐Enin, Yomna A Salem, Saadia M El‐Ashry, Mohammed EA Hammouda, Journal of the Chinese Chemical Society 68 (9), 1686-1696‏, 2021 Eco-Friendly Green Liquid Chromatographic Separations of a Novel Combination of Azelastine and Fluticasone in the Presence of Their Pharmaceutical Dosage form Additives‏, Saadia M. El-Ashry. Amal A. El-Masry, Mohammed E. A. Hammouda*, Dalia R. El-Wasseef, Current Analytical Chemistry 16 (3), 277-286‏, 2020 Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler ‏, Yomna A Salem, Mohammed EA Hammouda, Mohamed A Abu El-Enin, Saadia M El-Ashry‏, BMC chemistry 13 (1), 75‏, 2019 Application of derivative emission fluorescence spectroscopy for determination of ibuprofen and phenylephrine simultaneously in tablets and biological fluids‏, Yomna A Salem, Mohammed EA Hammouda, Mohamed A Abu El-Enin, Saadia M El-Ashry, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 210, 387-397, ‏2019 Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: dual cyclooxygenase/carbonic anhydrase inhibitory actions ‏, A-M Alaa, Andrea Angeli, Adel S El-Azab, Mohammed EA Hammouda, Magda A El-Sherbeny, Claudiu T Supuran, Bioorganic chemistry 84, 260-268‏, 2019 Eco-friendly green liquid chromatographic determination of azelastine in the presence of its degradation products: Applications to degradation kinetics‏, Amal A El-Masry, Mohammed EA Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of AOAC International 102 (1), 81-90, 2019‏ Validated ion pair chromatographic method for simultaneous determination and in vitro dissolution studies of indacaterol and glycopyrronium from inhaled capsule dosage form‏, Yomna A Salem, Mohammed EA Hammouda, Noha M Saleh, Mohamed A Abu El-Enin, Saadia M El-Ashry, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 204, 464-474‏, 2018 Simultaneous determination of gatifloxacin and prednisolone in their bulk powder, synthetic mixture and their combined ophthalmic preparation using micellar liquid chromatography‏, Reem N El Gammal, Mohammed EA Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of chromatographic science 56 (4), 367-374, ‏2018 Validated spectroscopic methods for determination of anti-histaminic drug azelastine in pure form: Analytical application for quality control of its pharmaceutical preparations‏, Amal A El-Masry, Mohammed EA Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 191, 413-420‏, 2018 Validated sensitive spectrofluorimetric method for determination of antihistaminic drug azelastine HCl in pure form and in pharmaceutical dosage forms: application to stability study, ‏Amal A El‐Masry, Mohammed EA Hammouda, Dalia R El‐Wasseef, Saadia M El‐AshryLuminescence 32 (2), 177-181‏, 2017 Validated spectrofluorimetric method for determination of two phosphodiesterase inhibitors tadalafil and vardenafil in pharmaceutical preparations and spiked human plasma‏, Mohammed Abu Bakr Abu El‐Enin, Mohammed El‐Sayed Abd Al‐Ghaffar Hammouda, Dina Tawfik El‐Sherbiny, Dalia Rashad El‐Wasseef, Saadia Mahmoud El‐Ashry, Luminescence 31 (1), 173-178‏,2016 Simultaneous determination of enalapril and hydrochlorothiazide in pharmaceutical preparations using microemulsion liquid chromatography‏, Mohammed EA Hammouda, Mohamed A Abu El-Enin, Dina T El-Sherbiny, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of chromatographic science 53 (1), 90-96‏, 2015 Microemulsion liquid chromatographic method for simultaneous determination of simvastatin and ezetimibe in their combined dosage forms‏, Mohammed EA Hammouda, Mohamed A Abu El-Enin, Dina T El-Sherbiny, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of analytical methods in chemistry, 2013 Spectrofluorimetric determination of two β-agonist drugs in bulk and pharmaceutical dosage forms via derivatization with dansyl chloride‏, ME Abd El-Ghaffar, DR El-Wasseef, DT El-Sherbiny, SM El-Ashry, Journal of Analytical Chemistry 66, 476-481, 2011‏ Simultaneous determination of ritodrine and isoxsuprine in pharmaceutical preparations using liquid chromatography‏, Dina T El-Sherbiny, Mohammed E Abd El-Ghaffar, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of liquid chromatography & related technologies 33 (15), 1476-1486, ‏2010 Simultaneous determination of ritodrine and isoxsuprine using coupling technique of synchronous fluorimetry and h-point standard addition method‏, Dina T El-Sherbiny, Dalia R El-Wasseef, Mohammed E Abd El-Ghaffar, Saadia M El-Ashry, Journal of fluorescence 20, 251-260, ‏2010 Spectrophotometric methods for determination of ritodrine in bulk and in pharmaceutical dosage forms‏, Mohamed Abd El-Ghaffar, Dina El-Sherbiny, Dalia El-Wasseef, Saadia El-Ashry, Journal of Food and Drug Analysis 16 (2)‏, 2008 Validated Spectrofluorimetric Determination of Gemifloxacin in Pharmaceutical Preparations and Spiked Human Plasma, ‏Reem N El Gammal, Mohammed EA Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry, Journal of advances in chemistry, 2016	Prof. Mohamed El-Sayed Abd El-Ghaffar
4(3H) Quinazolones as beta-adrenergic blockers, 1981 Synthesis and antibacterial activity of some 4(3H)quinazolones, 1979	Dr. Mohsen Bebars
A) Publications with peer review process Ashraf K. El-Damasy, Jong Min Oh, Hyun Ji Kim, Seul-Ki Mun, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Yu-Jeong Choi, Jong-Jin Kim, Ghilsoo Nam, Hoon Kim, Gyochang Keum: Novel coumarin benzamides as potent and reversible monoamine oxidase-B inhibitors: Design, synthesis, and neuroprotective effects, Bioorganic Chemistry, 2023, p 106939. https://doi.org/10.1016/j.bioorg.2023.106939 Ahmed A Gaber, Marwa Sharaky, Ayman Abo Elmaaty, Mohamed M Hammouda, Ahmed AE Mourad, Samy Y Elkhawaga, Mahmoud Mohamed Mokhtar, Amr S Abouzied, Mai AE Mourad & Ahmed A Al-Karmalawy: Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers, Future Medicinal Chemistry, 2023. https://doi.org/10.4155/fmc-2023-0156 Eslam M. Abbass, Ahmed A. Al-Karmalawy, Marwa Sharaky, Muhammad Khattab, Abdullah Yahya Abdullah Alzahrani, Aya I. Hassaballah: Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer, Bioorganic Chemistry, 2023, p 106936. https://doi.org/10.1016/j.bioorg.2023.106936 Samar A. Antar, Nada A. Ashour, Marwa Sharaky, Muhammad Khattab, Naira A. Ashour, Roaa T. Zaid, Eun Joo Roh, Ahmed Elkamhawy, Ahmed A. Al-Karmalawy: Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments, Biomedicine & Pharmacotherapy, 2023, p 115734. https://doi.org/10.1016/j.biopha.2023.115734 maiy Y. Jaballah, Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Khaled A. M. Abouzid: Pyridazine Based Compounds with PARP-1 Inhibitory Activity, Archives of Pharmaceutical Sciences Ain Shams University, 2023, p 274-285. http://dx.doi.org/10.21608/APS.2023.224318.1127 Ahmed Mowafy Tafish, Mohamed El-Sherbiny, Ahmed A Al‐Karmalawy, Osama Abd El-Azeem Soliman & Noha Mohamed Saleh: Carvacrol-Loaded Phytosomes for Enhanced Wound Healing: Molecular Docking, Formulation, DoE-Aided Optimization, and in vitro/in vivo Evaluation, International Journal of Nanomedicine, 2023, p 5749-5780. https://doi.org/10.2147/IJN.S421617 Samar A. Antar, Aymen Halouani, Cherry Gad, Ahmed A. Al-Karmalawy: An Overview of the Mechanisms of Cadmium-induced Toxicity in the Male Reproductive System, Pharmaceutical Sciences, 2023, p 30. https://doi.org/10.34172/PS.2023.10 Mohamed Y. Zakaria, Marwa Sharaky, Ayman M. Noreddin, Radwan Alnajjar, Rabeh EL-Shesheny, Omnia Kutkat, Mohamed E. El‐Beeh, Mohammed A.S. Abourehab, Ahmed A. Al-Karmalawy: Investigating the superiority of chitosan/D-alpha-tocopheryl polyethylene glycol succinate binary coated bilosomes in promoting the cellular uptake and anti-SARS-CoV-2 activity of polyphenolic herbal drug candidate, International Journal of Pharmaceutics, 2023, p 123385. https://doi.org/10.1016/j.ijpharm.2023.123385 Ahmed S. Mohamed, Osama G. Mohamed, Ali M. El Shamy, Fatma S. El Sakhawy, Ahmed A. Al‐Karmalawy, Ashootosh Tripathi, Rania A. El Gedaily: Anti-Alzheimer Activity and UHPLC-MS Based Molecular Networking of Pseudobombax ellipticum Cultivars Coupled to Multivariate Data Analysis and In Silico Molecular Docking, Egyptian Journal of Chemistry, 2023. https://doi.org/10.21608/ejchem.2023.224319.8292 Aya S. Shalaby, Hanaa H. Eid, Riham A. El-Shiekh, Fadia S. Youssef, Ahmed A. Al-Karmalawy, Nahla A. Farag, Amany A. Sleem, Fatma Adly Morsy, Khaled M. Ibrahim, Soad H. Tadros: A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb-Drug Interactions in Preventing Paracetamol-Induced Hepatotoxicity, Chemistry & Biodiversity, p 202300778, 2023. https://doi.org/10.1002/cbdv.202300778 Saad Shaaban, Ahmed A. Al-Karmalawy, Abdulrahman G. Alhamzani, Mortaga M. Abou–Krisha, Mahmoud A. Al–Qudah, and Tarek A. Yousef: Synthesis and Molecular Docking Analysis of New Thiazo-Isoindolinedione Hybrids as Potential Inhibitors of the SARS-Cov-2 Main Protease, Oriental Journal of Chemistry, 2023. http://dx.doi.org/10.13005/ojc/390412 Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee and Ahmed A. Al-Karmalawy: Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers, Journal of Enzyme Inhibition and Medicinal Chemistry, p 2242714, 2023. https://doi.org/10.1080/14756366.2023.2242714 Mohamed A. Salem, Osama G. Mohamed, Esraa M. Mosalam, Aya Ibrahim Elberri, Hend Mohamed Abdel-Bar, Mariam Hassan, Ahmed A. Al-Karmalawy, Ashootosh Tripathi, Shahira M. Ezzat and Hend E. Abo Mansour: Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste, Scientific Reports, 2023, p 13034. https://doi.org/10.1038/s41598-023-38591-y Saad Shaaban, Yasair S. Al-Faiyz, Ghayah M. Alsulaim, Mohamed Alaasar, Nasser Amri, Hussein Ba-Ghazal, Ahmed A. Al-Karmalawy and Aly Abdou: Synthesis of New Organoselenium-Based Succinanilic and Maleanilic Derivatives and In Silico Studies as Possible SARS-CoV-2 Main Protease Inhibitors, Inorganics, 2023, p 321. https://doi.org/10.3390/inorganics11080321 Ahmed A. Al-Karmalawy, Radwan Alnajjar, Ayman Abo Elmaaty, Faizah A. Binjubair, Sara T. Al-Rashood, Basma S. Mansour, Ahmed Elkamhawy, Wagdy M. Eldehna & Khaled Ahmed Mansour: Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in virto assessments with structure-activity relationship, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, p 1-13. https://doi.org/10.1080/07391102.2023.2240419 Ahmed A. Al-Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, Haytham O. Tawfik, Moataz A. Shaldam: Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments, European Journal of Medicinal Chemistry, 2023, p 115661. https://doi.org/10.1016/j.ejmech.2023.115661 Aya S. Shalaby, Hanaa H. Eid, Riham A. El-Shiekh, Osama G. Mohamed, Ashootosh Tripathi, Ahmed A. Al-Karmalawy, Amany A. Sleem, Fatma Adly Morsy, Khaled M. Ibrahim, Soad H. Tadros, and Fadia S. Youssef: Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity, ACS Omega, 2023, p 26444-26457. https://doi.org/10.1021/acsomega.3c03100 Samar A. Antar, Ayman M. Mahmoud, Walied Abdo, Cherry Gad, and Ahmed Ali Al-Karmalawy: A Comprehensive Overview of Organ Inflammatory Responses: Genesis, Possible Mechanisms, and Mediators of Inflammation, Pharmaceutical Sciences, 2023, p 397-416. http://dx.doi.org/10.34172/PS.2023.9 Seham S El-Hawary, Abeer S Moawad, Hebatallah S Bahr, Eman Z Attia, Mo`men H El-Katatny, Muhamad Mustafa, Ahmed A Al-Karmalawy, Mostafa E Rateb, Jian-ye Zhang, Usama Ramadan Abdelmohsen, Rabab Mohammed: Promising Cytotoxic butenolides from the Soybean endophytic fungus Aspergillus terreus: a combined molecular docking and in-vitro studies, Journal of Applied Microbiology, 2023, p 129. https://doi.org/10.1093/jambio/lxad129 Samar El-Kalyoubi, Samar S Elbaramawi, Ahmed G Eissa, Essam Al-Ageeli, Yahya Hasan Hobani, Aya Ali El-Sharkawy, Hossam Taha Mohamed, Ahmed A Al-Karmalawy, and Hamada S Abulkhair: Design and synthesis of novel uracil-linked Schiff bases as dual histone deacetylase type II/topoisomerase type I inhibitors with apoptotic potential, Future Medicinal Chemistry, 2023, p 937-958. https://doi.org/10.4155/fmc-2023-0112 Ahmed Kandeil, Mounir Abi-Said, Rebecca Badra, Rabeh El-Shesheny, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Zumama Khalid, Mina Nabil Kamel, Walid Abi Habib, Jad Abdallah,Vijaykrishna Dhanasekaran, Richard Webby, and Ghazi Kayali: Detection of Coronaviruses in Bats in Lebanon during 2020, Pathogens, 2023, p 876. https://doi.org/10.3390/pathogens12070876 Nader R. Albujuq, Khalid Althumayri, Reem A. K Alharbi, Ahmed A. Al-Karmalawy, Mohamed S. Nafie: Design and Synthesis of Benzenesulfonamides Coupled with Piperidine, Morpholine, and N,N-Dimethylethanamine Moieties as Apoptotic Inducers through VEGFR2 and Topoisomerase II Inhibition, Chemistry Select, 2023, p 202301315. https://doi.org/10.1002/slct.202301315 Amany Belal, Mohamed A. Elanany, Ahmed A. Al-Karmalawy, Ahmed Elkamhawy, Mohammed A. S. Abourehab, Heba I. Ghamry & Ahmed B. M. Mehany: Design of new captopril mimics as promising ACE inhibitors: ADME, pharmacophore, molecular docking and dynamics simulation with MM-PBSA and PCA calculations, Journal of Taibah University for Science, 2023, p 2210348. https://doi.org/10.1080/16583655.2023.2210348 Mai A. E. Mourad, Ayman Abo Elmaaty, Islam Zaki, Ahmed A. E. Mourad, Amal Hofni, Ahmed E. Khodir, Esam M. Aboubakr, Ahmed Elkamhawy, Eun Joo Roh & Ahmed A. Al-Karmalawy: Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, p 2205043. https://doi.org/10.1080/14756366.2023.2205043 Ahmed A. Hamed, Osama G. Mohamed, Elsayed A. Aboutabl, Fify I. Fathy, Ghada A. Fawzy, Riham A. El-Shiekh, Ahmed A. Al-Karmalawy, Areej M. Al-Taweel, Ashootosh Tripathi and Tarek R. Elsayed: Identification of Antimicrobial Metabolites from the Egyptian Soil-Derived Amycolatopsis keratiniphila Revealed by Untargeted Metabolomics and Molecular Docking, Metabolites, 2023, p 620. https://doi.org/10.3390/metabo13050620 Ayman Abo Elmaaty, Ahmed A. Al-Karmalawy, Mohamed S. Nafie, Marium M. Shamaa, Islam Zaki, Radwan Alnajjar, Mohamed Y. Zakaria: Experimental Design of D-α-tocopherol polyethylene glycol 1000 succinate Stabilized Bile Salt Based Nano-vesicles for Improved Cytotoxicity and Bioavailability of Colchicine Binding Site Inhibitor Candidates: In Vitro, In silico, and Pharmacokinetic Studies, International Journal of Pharmaceutics, 2023, p 122980. https://doi.org/10.1016/j.ijpharm.2023.122980 Seohyun Son, Ahmed Elkamhawy, Anam Rana Gul, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Ahmed Abdeen, Samah F. Ibrahim, Saud O. Alshammari, Qamar A. Alshammari, Won Jun Choi, Tae Jung Park & Kyeong Lee: Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, p 2202358. https://doi.org/10.1080/14756366.2023.2202358 Ahmed A. Al-Karmalawy, Dalia S. El-Gamil, Rabeh El-Shesheny, Marwa Sharaky, Radwan Alnajjar, Omnia Kutkat, Yassmin Moatasim, Mohamed Elagawany, Sara T. Al-Rashood, Faizah A. Binjubair, Wagdy M. Eldehna, Ayman M. Noreddin & Mohamed Y. Zakaria: Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, p 2202357. https://doi.org/10.1080/14756366.2023.2202357 Samia M. Al-Muntaser, Ahmed A. Al-Karmalawy, Abeer M. El-Naggar, Ali Khalil Ali, Nour E. A. Abd El-Sattar and Eslam M. Abbass: Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, and in silico studies, RSC Advances, 2023, p 12184-12203. https://doi.org/10.1039/D3RA00416C Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed, Ahmed S. Doghish, Radwan Alnajjar, Ahmed A. Al-Karmalawy, Asmaa E. Kassab: Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease, Drug Development Research, 2023, p 937-961. https://doi.org/10.1002/ddr.22064 Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali &Ahmed M. El-Agrody: A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses, Journal of Biomolecular Structure and Dynamics, 2023, p 1-19. https://doi.org/10.1080/07391102.2023.2188957 Ahmed A. Hamed, Riham A. El-Shiekh, Osama G. Mohamed, Elsayed A. Aboutabl, Fify I. Fathy, Ghada A. Fawzy, Areej M. Al-Taweel, Tarek R. Elsayed, Ashootosh Tripathi, and Ahmed A. Al-Karmalawy: Cholinesterase Inhibitors from an Endophytic Fungus Aspergillus niveus Fv-er401: Metabolomics, Isolation and Molecular Docking, Molecules, 2023, p 2559. https://doi.org/10.3390/molecules28062559 Samar A. Antar, Nada A. Ashour, Mohamed E. Marawan and Ahmed A. Al-Karmalawy: Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation, International Journal of Molecular Sciences, 2023, p 4004. https://doi.org/10.3390/ijms24044004 Magda Assem, Rady E. El-Araby, Ahmed A. Al-Karmalawy, Reem Nabil, Mohamed A. M. Kamal, Amany Belal, Heba I. Ghamry, Mohammed A. S. Abourehab, Mohammed M. Ghoneim, Mohammad Y. Alshahrani and Asmaa A. El Leithy: Promoter methylation might shift the balance of Galectin-3 & 12 expression in de novo adult acute myeloid leukemia patients, Frontiers in Genetics, 2023, p 1122864. https://doi.org/10.3389/fgene.2023.1122864 Yousra T. Eloutify, Riham A. El-Shiekh, Khaled Meselhy Ibrahim, Ahmed R. Hamed, Ahmed A. Al-Karmalawy, Aya A. Shokry, Yasmine H. Ahmed, Bharathi Avula, Kumar Katragunta, Ikhlas A. Khan & Meselhy R. Meselhy: Bioactive fraction from Plumeria obtusa L. attenuates LPS-induced acute lung injury in mice and inflammation in RAW 264.7 macrophages: LC/QToF-MS and molecular docking, Inflammopharmacology, 2023, p 859-875. https://doi.org/10.1007/s10787-023-01144-w Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi , Hazem E. Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd-Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al-Karmalawy, Mohamed Elagawany: 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments, European Journal of Medicinal Chemistry, 2023, p 115180. https://doi.org/10.1016/j.ejmech.2023.115180 Faten Farouk, Ayman Abo Elmaaty, Ahmed Elkamhawy, Haytham O. Tawfik, Radwan Alnajjar, Mohammed A. S. Abourehab, Mohamed A. Saleh, Wagdy M. Eldehna & Ahmed A. Al-Karmalawy: Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, p 2171029. https://doi.org/10.1080/14756366.2023.2171029 Arafa Musa, Saleh K. Ihmaid, David L. Hughes, Musa A. Said, Hamada S. Abulkhair, Ahmed H. El-Ghorab, Mohamed A. Abdelgawad, Khaled Shalaby, Mohamed E. Shaker, Khalid Saad Alharbi, Nasser Hadal Alotaibi, Deborah L. Kays, Laurence J. Taylor, Della Grace Thomas Parambi, Sami I. Alzarea, Ahmed A. Al-Karmalawy, Hany E. A. Ahmed &Ahmed M. El-Agrody: The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations, Journal of Biomolecular Structure and Dynamics, 2023, p 1-15. https://doi.org/10.1080/07391102.2023.2167000 Ahmed Elkamhawy, Na Kyoung Oh, Noha A. Gouda, Magda H. Abdellattif, Saud O. Alshammari, Mohammed A. S. Abourehab, Qamar A. Alshammari, Amany Belal, Minkyoung Kim, Ahmed A. Al-Karmalawy* and Kyeong Lee: Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations, Metabolites, 2023, p 141. https://doi.org/10.3390/metabo13020141 Amany A. Alzokaky, Ahmed A. Al-Karmalawy, Mohamed A. Saleh, Walied Abdo, Amira E. Farag, Amany Belal, Mohammed A.S. Abourehab, Samar A. Antar: Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice, Life Sciences, 2023, p 121390. https://doi.org/10.1016/j.lfs.2023.121390 Ahmed Elkamhawy, Seohyun Son, Hwa Young Lee, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Saud O. Alshammari, Abeer A. Abdelhameed, Qamar A. Alshammari, Ahmed Abdeen, Samah F. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Radwan Alnajjar, Won Jun Choi, Ahmed A. Al-Karmalawy, and Kyeong Lee: Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives, Pharmaceuticals, 2022, p 43. https://doi.org/10.3390/ph16010043 Ahmed A. Al‐Karmalawy, Mohamed S. Nafie, Moataz A. Shaldam, Ayman Abo Elmaaty, Samar A. Antar, Anwar A. El-Hamaky, Mohamed A. Saleh, Ahmed Elkamhawy, and Haytham O. Tawfik: Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations, Journal of Medicinal Chemistry, 2022, p 777–792. https://doi.org/10.1021/acs.jmedchem.2c01668 Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Mohamed M. Khalifa, Mohamed S. Nafie, Mohamed A. Saleh, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Wagdy M. Eldehna, and Ahmed A. Al‐Karmalawy: Design and Synthesis of Novel Rigid Dibenzo[b,f]azepines Through Ring Closure Technique as Promising Anticancer Candidates Against Leukemia and Acting as Selective Topoisomerase II Inhibitors and DNA Intercalators, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 2157825. https://doi.org/10.1080/14756366.2022.2157825 Sanaa A. Ahmed, Moumen S. Kamel, Moustafa O. Aboelez, Xiang Ma, Ahmed A. Al-Karmalawy, Sayed A. S. Mousa, Elders Kh. Shokr, H. Abdel-Ghany, Amany Belal, Mohamed A. El Hamd, Zafer S. Al Shehri, and Mahmoud Abd El Aleem Ali Ali El-Remaily: Thieno[2,3b]thiophene Derivatives as Potential EGFRWT and EGFRT790M Inhibitors with Antioxidant Activities: MicrowaveAssisted Synthesis and Quantitative In Vitro and In Silico Studies, ACS Omega, 2022, p 45535–45544. https://doi.org/10.1021/acsomega.2c06219 Mai E. Hussein, Osama G. Mohamed, Ahlam M. El-Fishawy, Hesham I. El-Askary, Ahmed A. Hamed, Marwa M. Abdel-Aziz, Radwan Alnajjar, Amany Belal, Ahmed M. Naglah, Abdulrahman A. Almehizia, Ahmed A. Al-Karmalawy, Ashootosh Tripathi and Amira S. El Senousy: Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies, Plants, 2022, p 3286. https://doi.org/10.3390/plants11233286 Howaida I. Abd-Alla, Omnia Kutkat, Heba-tollah M. Sweelam, Wagdy M. Eldehna, Marwa A. Mostafa, Magda T. Ibrahim, Yassmin Moatasim, Mohamed GabAllah and Ahmed A. Al-Karmalawy: Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies, Metabolites, 2022, p 1109. https://doi.org/10.3390/metabo12111109 Mohamed Kh. ElMahdy, Mennatallah O. Zaki, Ahmed A. Al-Karmalawy, Walied Abdo, Sulaiman Mohammed Alnasser, Samar A. Antar: Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways, Life Sciences, 2022, p 121184. https://doi.org/10.1016/j.lfs.2022.121184 Tarfah Al-Warhi, Diaaeldin M. Elimam, Zainab M. Elsayed, Marwa M. Abdel-Aziz, Raed M. Maklad, Ahmed A. Al-Karmalawy, Kamyar Afarinkia, Mohammed A. S. Abourehab, Hatem A. Abdel-Azizj and Wagdy M. Eldehna: Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens, RSC Advances, 2022, p 31466-31477. https://doi.org/10.1039/D2RA04385H Tarfah Al-Warhi, Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel-Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna & Marwa Sharaky: Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 176-191. https://doi.org/10.1080/14756366.2022.2135512 Ayman Abo Elmaaty, Wagdy M. Eldehna , Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed N. El-Taweel, Sara T. Al-Rashood, Mohammed A. S. Abourehab, Faizah A. Binjubair, Mohamed A. Saleh, Amany Belal and Ahmed A. Al-Karmalawy: Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies, International Journal of Molecular Sciences, 2022, p 12235. https://doi.org/10.3390/ijms232012235 Samar A. Antar, Mohamed A. Saleh, Ahmed A. Al-Karmalawy: Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2, Life Sciences, 2022, p 121048. https://doi.org/10.1016/j.lfs.2022.121048. Eman A. Madbouly, El-Sayed M. Lashine, Ahmed A. Al-Karmalawy, Mahmoud M. Sebaiy, Harris Pratsinis, Dimitris Kletsas and Kamel Metwally: Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and SAR studies, New Journal of Chemistry, 2022, p 22013-22029. https://doi.org/10.1039/D2NJ04053K Tarfah Al-Warhi, Mostafa M. Elbadawi, Alessandro Bonardi, Alessio Nocentini, Ahmed A. Al-Karmalawy, Nada Aljaeed, Ohoud J. Alotaibi, Hatem A. Abdel-Aziz, Claudiu T. Supuran &Wagdy M. Eldehna: Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 2635-2643. https://doi.org/10.1080/14756366.2022.2124409 Ateyatallah Aljuhani, Hany E. A. Ahmed, Saleh K. Ihmaid, Abdelsattar M. Omar, Sultan S. Althagfan, Yaser M. Alahmadi, Iqrar Ahmad, Harun Patel, Sahar Ahmed, Mohannad A. Almikhlafi, Ahmed M. El-Agrody, Mohamed F. Zayed, Safaa Abdulrahman Turkistani, Shorouk H. Abulkhair, Mohammed Almaghrabi, Samir A. Salama, Ahmed A. Al-Karmalawy and Hamada S. Abulkhair: In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-MPro inhibitors, RSC Advances, 2022, p 26895-26907. https://doi.org/10.1039/D2RA04015H Amany Belal, Hazem Elkady, Ahmed A. Al-Karmalawy, Ali H. Amin, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Rasha Hamed Al-Serwi, Mohamed Attia Abdou, Mona H. Ibrahim and Ahmed B. M. Mehany: Discovery of Some Heterocyclic Molecules as Bone Morphogenetic Protein 2 (BMP-2)-Inducible Kinase Inhibitors: Virtual Screening, ADME Properties, and Molecular Docking Simulations, Molecules, 2022, p 5571. https://doi.org/10.3390/molecules27175571 Wael H. Roshdy, Mohamed K. Khalifa, James Emmanuel San, Houriiyah Tegally, Eduan Wilkinson, Shymaa Showky, Darren Patrick Martin, Monika Moir, Amel Naguib, Nancy Elguindy, Mokhtar R. Gomaa, Manal Fahim, Hanaa Abu Elsood, Amira Mohsen, Ramy Galal, Mohamed Hassany, Richard J. Lessells, Ahmed A. Al-Karmalawy, Rabeh EL-Shesheny, Ahmed M. Kandeil, Mohamed A. Ali and Tulio de Oliveira: SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic, Viruses, 2022, p 2283-2303. https://doi.org/10.3390/v14091878 Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab, Ahmed A. Al-Karmalawy, Mostafa. A. Elhendawy, Mohamed. M. Radwan, Eslam B. Elkaeed, Ibrahim M. Ibrahim, Heba S. A. Elzahabi & Ibrahim H. Eissa: Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 2283-2303. https://doi.org/10.1080/14756366.2022.2112575 Khaled Ahmed Mansour, Ahmed Elbermawi, Ahmed A. Al-Karmalawy, Mohamed-Farid Lahloub & Mona El-Neketi: Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile, Pharmaceutical Biology, 2022, p 1374-1383. https://doi.org/10.1080/13880209.2022.2098346 Mohamed A. Salem, Riham A. El-Shiekh, Nora M. Aborehab, Ahmed A. Al‐Karmalawy, Shahira M. Ezzat, Saleh Alseekh, Alisdair R. Ferni: Metabolomics driven analysis of Nigella sativa seeds identifies the impact of roasting on the chemical composition and immunomodulatory activity, Food Chemistry, 2022, p 133906. https://doi.org/10.1016/j.foodchem.2022.133906 Mahmoud M. A. Elsayed, Moustafa O. Aboelez, Mohamed S. Mohamed, Reda A. Mahmoud, Ahmed A. El-Shenawy, Essam A. Mahmoud, Ahmed A. Al-Karmalawy, Eman Y. Santali, Sameer Alshehri, Mahmoud Elkot Mostafa Elsadek, Mohamed A. El Hamd, and Abd El hakim Ramadan: Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study, Pharmaceutics, 2022, p 1629. https://doi.org/10.3390/pharmaceutics14081629 Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M. Abo Shama, Eman Y. Santali, Bahaa Elgendy, and Ahmed A. Al-Karmalawy: Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 2112-2132. http://dx.doi.org/10.1080/14756366.2022.2105322 Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair, Mokhtar R. Gomaa, Ahmed N. El-Taweel, Noura M. Abo Shama, Mohamed GabAllah, Dina B. Mahmoud, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil & Ahmed Mostafa: Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies, Scientific Reports, 2022, p 12920. http://dx.doi.org/10.1038/s41598-022-17082-6 Wael H. Roshdy, Ahmed Kandeil, Rabeh El-Shesheny, Mohamed K. Khalifa, Ahmed A. Al-Karmalawy, Shymaa Showky, Amel Naguib, Nancy Elguindy, Manal Fahim, Hanaa Abu Elsood, Ahmed El Taweel, Azza Salamony, Amira Mohsen, Ghazi Kayali, Mohamed A. Ali, and Amr Kandeel: Insight into Genetic Characteristics of Identified SARS-CoV-2 Variants in Egypt from March 2020 to May 2021, Pathogens, 2022, p 834. https://doi.org/10.3390/pathogens11080834 Amany Belal, Nagwa M. Abdel Gawad, Ahmed B. M. Mehany, Mohammed A. S. Abourehab, Hazem Elkady, Ahmed A. Al‐Karmalawy & Ahmed S. Ismael: Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 1884–1902. https://doi.org/10.1080/14756366.2022.2096019 Enas Abdelhameed Mahmoud HUSEEIN, Mohamed SAMIR, Ahmed A. AL-KARMALAWY, Shimaa S. HASSAN, Mona EMBAREK MOHAMED, Fatma Abdel Aziz Mohamed MOSTAFA, Ahmed M. MOHARRAM, Samia S. ALKHALIL, Haiam Mohamed Mahmoud FARRAG: Ganoderma lucidum extract inhibits Schistosoma mansoni survival in silico and in vitro study, Annals of Parasitology, 2022, p 323-330. https://doi.org/10.17420/ap6802.438 Mohamed M. Hammouda, Ayman Abo Elmaaty, Mohamed S. Nafie, Marwa Abdel-Motaal, Noha S. Mohamed, Mohamed A. Tantawy, Amany Belal, Radwan Alnajjar, Wagdy M. Eldehna, Ahmed A. Al-Karmalawy: Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies, Bioorganic Chemistry, 2022, p 105995. https://doi.org/10.1016/j.bioorg.2022.105995 Eman Zekry Attia, Basma Ali Khalifa, Gehan M. Shaban, Mohamed N. Amin, Lina Akil, Ibrahim Khadra, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Marco Y. W. Zaki, Omar M. Aly, Mo'men H. El-Katatny, Usama Ramadan Abdelmohsen: Potential topoisomerases inhibitors from Asergillus terreus using virtual screening, South African Journal of Botany, 2022, p 632-645. https://doi.org/10.1016/j.sajb.2022.06.051 Mohamed M. Hammoud, Muhammad Khattab, Marwa Abdel-Motaal, Johan Van der Eycken, Radwan Alnajjar, Hamada S. Abulkhair & Ahmed A. Al-Karmalawy: Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity, Journal of Biomolecular Structure and Dynamics, 2022, p 5199-5216. https://doi.org/10.1080/07391102.2022.2082533 Mona F. El-Azab, Ahmed A. Al-Karmalawy, Samar A. Antar, Pierre A. Hanna, Karim M. Tawfik, Reem M. Hazem: A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways, Life Sciences, 2022, p 120691. https://doi.org/10.1016/j.lfs.2022.120691 Amany Belal, Mohamed A. Elanany, Eman Y. Santali, Ahmed A. Al-Karmalawy, Moustafa O. Aboelez, Ali H. Amin, Magda H. Abdellattif, Ahmed B. M. Mehany, and Hazem Elkady: Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management, Molecules, 2022, p 3584. https://doi.org/10.3390/molecules27113584 Mohamed M. Hammoud, Alaa S. Nageeb, M. A. Morsi, Esam Arafa Gomaa, Ayman Abo Elmaaty, and Ahmed A. Al-Karmalawy: Design, Synthesis, Biological Evaluation, and SAR Studies of Novel Cyclopentaquinoline Derivatives as DNA Intercalators, Topoisomerase II Inhibitors, and Apoptotic Inducers, New Journal of Chemistry, 2022, p 11422-11436. https://doi.org/10.1039/D2NJ01646 A. A. El Leithy, A. A. Al-Karmalawy, O. M. Youssif, Y. A. Ebrahim, A. S. Khalifa, E. B. Elkaeed, F. S. Abo-Zeid: Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model, European Review for Medical and Pharmacological Sciences, 2022, p 2740-2754. http://dx.doi.org/10.26355/eurrev_202204_28604 Rogy R. Ezz Eldin, Marwa A. Saleh, Mohammad Hayal Alotaibi, Reem K. Alsuair, Yahya A. Alzahrani, Feras A. Alshehri, Amany F. Mohamed, Shaimaa M. Hafez, Azza Ali Althoqapy, Seham K. Khirala, Mona M. Amin, Yousuf A. F, Azza H. AbdElwahab, Mohamed S. Alesawy, Ayman Abo Elmaaty, and Ahmed A. Al-Karmalawy: Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, p 1098-1119. https://doi.org/10.1080/14756366.2022.2063282 Rogy R. Ezz Eldin, Ahmed A. Al-Karmalawy, Mohammad Hayal Alotaibi, and Marwa A. Saleh: Quinoxaline derivatives as a promising scaffold for breast cancer treatment, New Journal of Chemistry, 2022, p 9975-9984. https://doi.org/10.1039/D2NJ00050D Abeer M. El-Naggar, A. M. A. Hassan, Eslam B. Elkaeed, Mohamed S.Alesawy, Ahmed A. Al‐Karmalawy: Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2, Bioorganic Chemistry, 2022, p 105770. http://dx.doi.org/10.1016/j.bioorg.2022.105770 Nada A Ashour, Ayman Abo Elmaaty, Amany A Sarhan, Eslam B Elkaeed, Ahmed M Moussa, Ibrahim Ali Erfan, Ahmed A Al-Karmalawy: A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval, Drug Design, Development and Therapy, 2022, p 685–715. https://doi.org/10.2147%2FDDDT.S354841 Richie R Bhandare, Chandrashekar S. Munikrishnappa, G.V. Suresh Kumar, Sathish Kumar Konidala, Dilep Kumar Sigalapalli, Yogesh Vaishnav, Sampath Chinnam, Haya Yasin, Ahmed A. Al-karmalawy, Afzal B.Shaik: Multistep synthesis and screening of heterocyclic tetrads containing furan, pyrazoline, thiazole and triazole (or oxadiazole) as antimicrobial and anticancer agents, Journal of Saudi Chemical Society, 2022, p 101447. https://doi.org/10.1016/j.jscs.2022.101447 Mohamed A. Salem, Nora M. Aborehab, Ahmed A. Al-Karmalawy, Alisdair R. Fernie, Saleh Alseekh, andS hahira M. Ezzat: Potential Valorization of Edible Nuts By-Products: Exploring the Immune-Modulatory and Antioxidants Effects of Selected Nut Shells Extracts in Relation to Their Metabolic Profiles, Antioxidants, 2022, p 462. https://doi.org/10.3390/antiox11030462 Rana El-Masry, Ahmed A. Al-Karmalawy, Radwan A Alnajjar, Sara Mahmoud, Ahmed Mostafa, Hanan Kadry, Sahar Abou-Seri, and Azza Taher: Newly Synthesized Series of Oxoindole-Oxadiazole Conjugates as Potential Anti-SARS-CoV-2 Agents: In Silico and In Vitro Studies, New Journal of Chemistry, 2022, p 5078-5090. https://doi.org/10.1039/D1NJ04816C Aml Ghanem, Ahmed A. Al-Karmalawy, Ahmed I. Abd El Maksoud, Shaden M. Hanafy, Hamdy A. Emara, Rasha M. Saleh, Mohamed F. Elshal: Rumex Vesicarius L. extract improves the efficacy of doxorubicin in triple-negative breast cancer through inhibiting Bcl2, mTOR, JNK1 and augmenting p21 expression, Informatics in Medicine Unlocked, 2022, p 100869. https://doi.org/10.1016/j.imu.2022.100869 Dina B. Mahmoud, Mohamed Mofreh Bakr, Ahmed A. Al-Karmalawy, Yassmin Moatasim, Ahmed El Taweel & Ahmed Mostafa: Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19, AAPS PharmSciTech, 2022, p 44. http://dx.doi.org/10.1208/s12249-021-02197-2 Ayman Abo Elmaaty, Khaled M. Darwish, Amani Chrouda, Amira A. Boseila, Mohamed A. Tantawy, Sameh S. Elhady, Afzal B. Shaik, Muhamad Mustafa, and Ahmed A. Al-karmalawy: In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity, ACS OMEGA, 2021, p 875–899. https://doi.org/10.1021/acsomega.1c05519 Dalia Elebeedy, Ingy Badawy, Ayman Abo Elmaaty, Moustafa M. Saleh, Ahmed Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, Ahmed I. Abd El Maksoud, Ahmed A. Al-karmalawy: In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus, Computers in Biology and Medicine, 2021, p 105149. https://doi.org/10.1016/j.compbiomed.2021.105149 Mohamed M. Khalifa, Ahmed A. Al-Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa & Hazem A. Mahdy: Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies, Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, p 299-314. https://doi.org/10.1080/14756366.2021.2007905 A. A. Mohamed, A. A. Al-Karmalawy, A.A. El-Kholy, D.A. El-Damas, H.M. Abostate, S.M. Mostafa, M. Hamada, M.A. Khalik Elkady, Y. Hassan, E. Al-Hussain, M.G. Khalil, I. Badawy, D. Elebeedy, B.A. Alsfouk, M.M. Shaheenl: Effect of Vitamin D supplementation in patients with liver cirrhosis having spontaneous bacterial peritonitis: a randomized controlled study, European Review for Medical and Pharmacological Sciences, 2021, p 6908-6919. https://doi.org/10.26355/eurrev_202111_27239 Reem M.Hazem, Samar A. Antar, Yossef K. Nafea, Ahmed A. Al-Karmalawy, Mohamed A. Salehd, Mona F. El-Azab: Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor, Life Sciences, 2021, p 120185. https://doi.org/10.1016/j.lfs.2021.120185 Ahmed A. Al-Karmalawy, Raya Soltane, Ayman Abo Elmaaty, Mohamed A. Tantawy, Samar A. Antar, Galal Yahya, Amani Chrouda, Rami Adel Pashameah, Muhamad Mustafa, Mobarak Abu Mraheil, and Ahmed Mostafa: Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview, Vaccines, 2021, p 1317. https://doi.org/10.3390/vaccines9111317 Mohammed I. A. Hamed, Khaled M. Darwish, Raya Soltane, Amani Chrouda, Ahmed Mostafa, Noura M. Abo Shama, Sameh S. Elhady, Hamada S. Abulkhair, Ahmed E. Khodir, Ayman Abo Elmaaty, and Ahmed A. Al-Karmalawy: β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization, RSC Advances, 2021, p 35536-35558. https://doi.org/10.1039/D1RA04820A Shenouda G. Elia, Ahmed A. Al-Karmalawy, Mohamed Y. Nasr, Mohamed F. Elshal: Loperamide potentiates doxorubicin sensitivity in triple-negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl-2: In vitro and molecular docking study, Journal of Biochemical and Molecular Toxicology, 2021, p 22938. https://doi.org/10.1002/jbt.22938 Mona A. Raslan, Rehab F. Taher, Ahmed A. Al-Karmalawy, Dalia El-Ebeedy, Angham G. Metwaly, Nourhan M. Elkateeb, Aml Ghanem, Reem A. Elghaishh, and Ahmed I. Abd El Maksoud: Cordyline fruticosa (L.) A. Chev. leaves: isolation, HPLC/MS profiling and evaluation of nephroprotective and hepatoprotective activities supported by molecular docking, New Journal of Chemistry, 2021, p 22216-22233. https://doi.org/10.1039/D1NJ02663A Ahmed A. Al-Karmalawy, Mai M. Farid, Ahmed Mostafa, Alia Y. Ragheb, Sara H. Mahmoud, Mahmoud Shehata, Noura M. Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, and Mona M. Marzouk: Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2, Molecules, 2021, p 6559. https://doi.org/10.3390/molecules26216559 Rana T. Diab, Zakaria K. Abdel-Sami, Eatedal H. Abdel-Aal, Ahmed A. Al-Karmalawy, and Nader E. Abo-Dya: Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies, New Journal of Chemistry, 2021, p 21657-21669. https://doi.org/10.1039/D1NJ02885E Tahsin Shoala, Ahmed A. Al-Karmalawy, Mousa O. Germoush, Salha M. ALshamrani, Mohamed A. Abdein and Nabil S. Awad: Nanobiotechnological Approaches to Enhance Potato Resistance against Potato Leafroll Virus (PLRV) Using Glycyrrhizic Acid Ammonium Salt and Salicylic Acid Nanoparticles, Horticulturae, 2021, p 402. https://doi.org/10.3390/horticulturae7100402 Mahmoud M. Shehata, Sara H. Mahmoud, Mohammad Tarek, Ahmed A. Al-Karmalawy, Amal Mahmoud, Ahmed Mostafa, Mahmoud M. Elhefnawi and Mohamed A. Ali: In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine, Molecules, 2021, p 6182. https://doi.org/10.3390/molecules26206182 Amal Mahmoud, Essam Kotb, Amany I. Alqosaibi, Ahmed A. Al-Karmalawy, Ibtesam S. Al-Dhuayan, Hameedah Alabkari: In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia, Heliyon, 2021, p 08148. https://doi.org/10.1016/j.heliyon.2021.e08148 Rehab F. Taher, Ahmed A. Al‐Karmalawy, Ahmed I. Abd El Maksoud, Hany Khalil, Amr Hassan, Ezzel-Din A. El-Khrisy, Walaa A. El-Kashak: Two new flavonoids and anticancer activity of Hymenosporum flavum: in vitro and molecular docking studies, Journal of Herbmed Pharmacology, 2021, p 443-458. http://dx.doi.org/10.34172/jhp.2021.52 Maged A. Aziz, Wesam S. Shehab, Ahmed A. Al-Karmalawy, Ahmed F. EL-Farargy and Magda H. Abdellattif: Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, and Molecular Docking Studies of Novel 1H-3-Indolyl Derivatives as Significant Antioxidants, International Journal of Molecular Sciences, 2021, p 10396. https://doi.org/10.3390/ijms221910396 Heba A. El Gizawy, Sylvia A. Boshra, Ahmed Mostafa, Sara H. Mahmoud, Muhammad I. Ismail, Aisha A. Alsfouk, Azza T. Taher and Ahmed A. Al-Karmalawy: Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies, Molecules, 2021, p 5844. http://dx.doi.org/10.3390/molecules26195844 Amr El-Demerdash‡, Ahmed A. Al-Karmalawy‡, Tarek Mohamed Abdel-Aziz, Sameh S. Elhady, Khaled M. Darwish and Ahmed H. E. Hassan: Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors, RSC Advances, 2021, p 31339-31363. https://doi.org/10.1039/D1RA05817G Ahmed A. Zakia, Ahmed A. Al-Karmalawy, Ahmed E. Khodir, Yasser A. El-Amier, Ahmed Ashour: Isolation of cytotoxic active compounds from Reichardia tingitana with investigation of apoptosis mechanistic induction: In silico, in vitro, and SAR studies, South African Journal of Botany, 2021, p 115-123. https://doi.org/10.1016/j.sajb.2021.08.006 Dina B. Mahmoud, Walaa M. Ismail, Yassmin Moatasim, Omnia Kutkat, Aliaa N. ElMeshad, Shahira M. Ezzat, Kadriya S. El Deeb, Ahlam M. El-Fishawy, Mokhtar R. Gomaa, Ahmed Kandeil, Ahmed A. Al-karmalawy, Mohamed A. Ali, Ahmed Mostafa: Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies, Journal of Drug Delivery Science and Technology, 2021, p 102845. https://doi.org/10.1016/j.jddst.2021.102845 Amal Mahmoud, Ahmed Mostafa, Ahmed A. Al-Karmalawy, Ahmad Zidan, Hamada S. Abulkhair, Sara H. Mahmoud, Mahmoud Shehata, Mahmoud M. Elhefnawi, Mohamed A. Ali: Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies, Heliyon,2021, p 07962. https://doi.org/10.1016/j.heliyon.2021.e07962 Dalia Elebeedy, Walid F. Elkhatib, Ahmed Kandeil, Aml Ghanem, Omnia Kutkat, Radwan Alnajjar, Marwa A. Saleh, Ahmed I. Abd El Maksoud, Ingy Badawy and Ahmed A. Al-Karmalawy: Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights, RSC Advances, 2021, p 29267-29286. https://doi.org/10.1039/d1ra05268c Ahmed A. Gaber, Ahmed M. El-Morsy, Farag F. Sherbiny, Ashraf H. Bayoumi, Kamal M. El-Gamal, Khaled El-Adl, Ahmed A. Al-Karmalawy, Rogy R. Ezz Eldin, Marwa A. Saleh, Hamada S. Abulkhair: Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies, Archiv der Pharmazie, 2021, p 2100258. https://doi.org/10.1002/ardp.202100258 Mohamed A. Soltan, Muhammad Alaa Eldeen, Nada Elbassiouny, Ibrahim Mohamed, Dalia A. El-damasy, Eman Fayad, Ola A. Abu Ali, Nermin Raafat, Refaat A. Eid and Ahmed A. Al-Karmalawy: Proteome Based Approach Defines Candidates for Designing a Multitope Vaccine against the Nipah Virus, International Journal of Molecular Sciences, 2021, p 9330. https://doi.org/10.3390/ijms22179330 Abdallah E. Abdallah, Mohamed S. Alesawy, Sally I. Eissa, Esmail M. El-Fakharany, Mohamed H. Kalab, Mohamed H. Sharaf, Noura M. Abo Shama, Sara H. Mahmoud,f Ahmed Mostafa, Ahmed A. Al-Karmalawy, and Hazem Elkady: Design and synthesis of new 4-(2- nitrophenoxy)benzamide derivatives as potential antiviral agents: molecular modeling and in vitro antiviral screening, New Journal of Chemistry, 2021, p 16557-16571. https://doi.org/10.1039/D1NJ02710G Chao Ma, Mohammed S. Taghour, Amany Belal, Ahmed Mehany, Naglaa Mostafa, Ahmed Nabeeh and Ibrahim Eissa, Ahmed A. Al-Karmalawy: Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies, Frontiers in Chemistry, 2021, p 725135. https://doi.org/10.3389/fchem.2021.725135 Mohamed H. El-Shershaby, Kamal M. El-Gamal, Ashraf H. Bayoumi, Khaled El-Adl, Mohamed Alswah, Hany E. A. Ahmed, Ahmed A. Al-Karmalamy and Hamada S. Abulkhair: The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors, New Journal of Chemistry, 2021, p 13986-14004. https://doi.org/10.1039/D1NJ02838C Ayman Abo Elmaaty, Mohammed I. A. Hamed, Muhammad I. Ismail, Eslam B. Elkaeed, Hamada S. Abulkhair, Muhammad Khattab and Ahmed A. Al-Karmalawy: Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization, Molecules, 2021, p 3772. https://doi.org/10.3390/molecules26123772 Mohamed A. Soltan, Nada Elbassiouny, Helmy Gamal, Eslam B. Elkaeed, Refaat A. Eid, Muhammad Alaa Eldeen and Ahmed A. Al-Karmalawy: In Silico Prediction of a Multitope Vaccine against Moraxella catarrhalis: Reverse Vaccinology and Immunoinformatics, Vaccines, 2021, p 669. https://doi.org/10.3390/vaccines9060669 Ahmed Kandeil, Ahmed Mostafa, Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al-Karmalawy, Adel A. Rashad, Ahmed E. Kayed, Azza E. Kayed, Rabeh El-Shesheny, Ghazi Kayali and Mohamed A. Ali: Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2, Pathogens, 2021, p 758. https://doi.org/10.3390/pathogens10060758 Mohamed H. El-Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Ahmed A. Al-Karmalawy, Ebtehal M. Husseiny, Mona S. El-Zoghbi, Hamada S. Abulkhair: From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity, Bioorganic & Medicinal Chemistry, 2021, p 116266. https://doi.org/10.1016/j.bmc.2021.116266 Amany A. Sarhan, Nada A. Ashour, Ahmed A. Al-Karmalawy: The journey of antimalarial drugs against SARS-CoV-2: Review article, Informatics in Medicine Unlocked, 2021, p 100604. https://doi.org/10.1016%2Fj.imu.2021.100604 Raya Soltane, Amani Chrouda, Ahmed Mostafa, Ahmed A. Al-Karmalawy, Karim Chouaïb, Abdelwaheb dhahri, Rami Adel Pashameah, Ahlam Alasiri, Omnia Kutkat, Mahmoud Shehata, Hichem Ben Jannet, Jawhar Gharbi and Mohamed A. Ali: Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate, Pathogens, 2021, p 623. https://doi.org/10.3390/pathogens10050623 Ahmed A. Zaki, Ahmed Ashour, Sameh S. Elhady, Khaled M. Darwish, Ahmed A. Al-Karmalawy: Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies, Journal of Traditional and Complementary Medicine, 2021, p 16-34. https://doi.org/10.1016/j.jtcme.2021.05.001 Mohamed F. Elshal, Norhan M. Eid, Ibrahim El-Sayed, Wael El-Sayed, Ahmed A. Al‐ Karmalawy: Concanavalin-A shows synergistic cytotoxicity with tamoxifen via inducing apoptosis in estrogen receptor-positive breast cancer: In vitro and molecular docking studies, Pharmaceutical Sciences, 2021, p 76-85. http://dx.doi.org/10.34172/PS.2021.22 Ahmed A. Al-Karmalawy, Mohammed A. Dahab, Ahmed M. Metwaly, Sameh S. Elhady, Eslam B. Elkaeed, Ibrahim Eissa, and Khaled M. Darwish: Molecular docking and dynamics simulation revealed the potential inhibitory activity of ACEIs against SARS-CoV-2 targeting hACE2 receptor, Frontiers in Chemistry, 2021, p 661230. https://doi.org/10.3389/fchem.2021.661230 Ayman Abo Elmaaty, Radwan Alnajjar, Mohammed I. A. Hamed, Muhammad Khattab, Mohamed M. Khalifa and Ahmed A. Al-Karmalawy: Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: theoretical study, RSC Advances, 2021, p 10027-10042. https://doi.org/10.1039/D0RA10674G Reham M. Samra, Amal F. Soliman, Ahmed A. Zakia, Ahmed Ashour, Ahmed A. Al-Karmalawy, Madiha A. Hassan, Ahmed M. Zaghloul: Bioassay-guided isolation of a new cytotoxic ceramide from Cyperus rotundus L., South African Journal of Botany, 2021, p 210-216. https://doi.org/10.1016/j.sajb.2021.02.007 M Khattab and Ahmed A. Al-Karmalawy: Revisiting Activity of Some Nocodazole Analogues as a Potential Anticancer Drugs Using Molecular Docking and DFT Calculations, Frontiers in Chemistry, 2021, p 628398. https://doi.org/10.3389/fchem.2021.628398 Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Mohammed M. Dahab, Ahmed. M. Metwaly, Ibrahim. H. Eissa: Molecular docking and dynamics simulations reveal the potential of anti-HCV drugs to inhibit COVID-19 main protease, Pharmaceutical Sciences, 2021, p 661230. http://dx.doi.org/10.34172/PS.2021.3 Radwan Alnajjar, Ahmed Mostafa, Ahmed Kandeil, Ahmed A. Al-Karmalawy: Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main protease, Heliyon, 2020, p 05641. https://doi.org/10.1016/j.heliyon.2020.e05641 Mohamed S. Alesawy, Ahmed A. Al‐Karmalawy, Eslam B. Elkaeed, Mohamed Alswah, Ahmed Belal, Mohammed S. Taghour, Ibrahim H. Eissa: Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors, Archiv der Pharmazie, 2020, p 2000237. https://doi.org/10.1002/ardp.202000237 Shenouda G. Eliaa, Ahmed A. Al-Karmalawy, Rasha M. Saleh, and Mohamed F. Elshal: Empagliflozin and Doxorubicin Synergistically Inhibit the Survival of Triple-Negative Breast Cancer Cells via Interfering with the mTOR Pathway and Inhibition of Calmodulin: In Vitro and Molecular Docking Studies, ACS Pharmacology & Translational Science, 2020, p 1330–1338. https://doi.org/10.1021/acsptsci.0c00144 Aml Ahmed Ghanem, Hamdy Emara, Shaden Hanafy, Ahmed Abd EL-Maksoud, Ahmed A. Al-Karmalawy* and Mohamed El Shal: Tanshinone IIA synergistically enhances the antitumor activity of Doxorubicin by interfering with PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies, New Journal of Chemistry, 2020, p 17374-17381. https://doi.org/10.1039/D0NJ04088F A. Zaki, Ahmed A. Al-Karmalawy, Y El-Amier, A. Ashour: Molecular docking reveals the potential of Cleome amblyocarpa isolated compounds to inhibit COVID-19 virus main protease, New Journal of Chemistry, 2020, p 16752-16758. https://doi.org/10.1039/D0NJ03611K Ahmed A. Al-Karmalawy*, M Khattab: Molecular modelling of mebendazole polymorphs as a potential colchicine binding site inhibitor, New Journal of Chemistry, 2020, p 13990-13996. https://doi.org/10.1039/D0NJ02844D B) The following below mentioned publications have evolved from my doctoral dissertation Abdel‐Ghany A. El‐Helby, Helmy Sakr, Ibrahim H. Eissa, Ahmed A. Al‐Karmalawy and Khaled El‐Adl: Benzoxazole/benzothiazole‐derivedVEGFR‐2inhibitors: Design, synthesis, molecular docking, and anticancer evaluations, Archiv der Pharmazie, 2019, p 1900178. https://doi.org/10.1002/ardp.201900178 Abdel‐Ghany A. El‐Helby, Helmy Sakr, Ibrahim H. Eissa, Hamada Abulkhair, Ahmed A. Al‐Karmalawy and Khaled El‐Adl: Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2inhibitors, Archiv der Pharmazie, 2019, p 1900113. https://doi.org/10.1002/ardp.201900113 B) The following below mentioned publications have evolved from my master dissertation M.K. Ibrahim, K. El-Adl, Ahmed A. Al-Karmalawy: Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substitutedquinazolin-4(3H)-ones, Bulletin of Faculty of Pharmacy, Cairo University, 2015, p 101-116. https://doi.org/10.1016/j.bfopcu.2015.05.001 M.K. Ibrahim, K. El-Adl, Ahmed A. Al-Karmalawy: Design, synthesis, molecular docking and biological evaluation of some novel quinazolin-4(3H)-one derivatives as anti-inflammatory agents, Azhar Journal of Pharmaceutical Sciences, Al Azhar University, 2012. https://www.researchgate.net/publication/341194096	Assist. Prof. Ahmed Ali Al-Karmalawy
Gastroenterology manifestations and COVID‐19 outcomes: A meta‐analysis of 25,252 cohorts among the first and second waves RM Elshazli, A Kline, A Elgaml, MH Aboutaleb, MM Salim, M Omar, ... Journal of Medical Virology 93 (5), 2740-2768 2021 Biological evaluation and molecular docking study of metabolites from Salvadora Persica L. Growing in Egypt MM Ghoneim, WM Afifi, M Ibrahim, M Elagawany, MT Khayat, ... Pharmacognosy Magazine 15 (61), 232-237 2019 Design, synthesis, biological activity and molecular modeling of new heterocyclic tetrazole derivatives SM Bayomi, MA Moustafa, AR Maarouf, MH Abutaleb J Am Sci 12 (1), 40-56 2016	Dr. Mohamed Hemdan Abutaleb
El-Gohary, N.S., Hawas, S.S., Gabr, M.T., Shaaban, M.I. and El-Ashmawy, M.B., 2019. New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities. Bioorganic Chemistry, 92, p.103109. Hawas, S.S., El-Gohary, N.S., Gabr, M.T., Shaaban, M.I. and El-Ashmawy, M.B., 2019. Synthesis, molecular docking, antimicrobial, antiquorum-sensing and antiproliferative activities of new series of pyrazolo [3, 4-b] pyridine analogs. Synthetic Communications, 49(19), pp.2466-2487. Hawas, S.S., El-Sayed, S.M., Elzahhar, P.A. and Moustafa, M.A., 2023. New 2-alkoxycyanopyridine derivatives as inhibitors of EGFR, HER2, and DHFR: Synthesis, anticancer evaluation, and molecular modeling studies. Bioorganic Chemistry, 141, p.106874	Dr. Lecturer Samia Salah Hawas
Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M) 1, 4, 5, 6, 7, 8-Hexahydroquinolines and 5, 6, 7, 8-tetrahydronaphthalenes: a new class of antitumor agents targeting the colchicine binding site of tubulin Synthesis of α-indolylacrylates as potential anticancer agents using a Brønsted acid ionic liquid catalyst and the butyl acetate solvent	TA. Mennatallah Ali Shaheen
Piperidine nucleus in the field of drug discovery, 2021 Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays, 2023	TA. Mennatallah M. Abdelshaheed

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