Organic Chemistry
Publications
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2024 1-New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modelingr FMA Krakisha, DIA Othman, WM El Husseiny, MNA Nasr Future Medicinal Chemistry, 1-16 2-Novel quinazolin-2-yl 1, 2, 3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study NFM El Hamaky, A Hamdi, WA Bayoumi, AA Elgazar, MNA Nasr Bioorganic Chemistry 148, 107437 3- Recent Studies on Aromatase and EGFR Involved in Breast Cancer and their Inhibitors FN Takla, W Bayoumi, S El-messery, M Nasr Delta University Scientific Journal 7 (1) 4- Targeting carbonic anhydrases II/IX/XII with novel series of coumarin-based compounds: Synthesis, biological activity and molecular dynamics analysis FN Takla, S Zaib, WA Bayoumi, K Shehzadi, SM El-Messery, S Anjum, ... Journal of Molecular Structure 1300, 137277 5- Benzimidazole based hybrids as privileged candidates for topoII inhibition: Design, synthesis and molecular modeling studies NA Nawareg, AS Mostafa, SM El-Messery, MNA Nasr Journal of Molecular Structure 1298, 137020 2023 6- Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study FN Takla, WA Bayoumi, SM El-Messery, MNA Nasr Scientific Reports 13 (1), 13370 |
Prof. Dr. Magda Nasr Ahmed Nasr |
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2024 1-Novel Quinoline-3, 4-dihydropyrimidinone Hybrids Privileged Scaffolds: Design, Synthesis, and Cytotoxic Evaluation BA Mansour, MA El-Sayed, M Massoud, W Bayoumi Delta University Scientific Journal 7 (1), , 2024 2023 2-Synthesis, antitumor activities, and molecular modeling of 4-anilinoquinazoline derivatives as EGFR-TK inhibitors AH Mohammed, RM Gomaa, MAA El-Sayed, KB Selim Pharmaceutical Chemistry Journal 57 (8), 1215-1229, 1, 2023 2022 3-Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer OA El-Khouly, MA Henen, MAA El-Sayed, SM El-Messery Scientific Reports 12 (1), 17104 4-Insights into modulating the monastrol scaffold: Development of new pyrimidinones as Eg5 inhibitors with anticancer activity MG Thabit, AS Mostafa, KB Selim, MAA Elsayed, MNA Nasr Archiv der Pharmazie 355 (10), 2200029 5- In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors B Mansour, WA Bayoumi, MA El‐Sayed, LA Abouzeid, MAM Massoud Chemical Biology & Drug Design 100 (1), 121-135 6- Synthesis, Antitumor Activities and Molecular Modelling of 4-Anilinoquinazoline Derivatives as EGFR-TK Inhibitors RM Gomaa, MA El-Sayed, KB Selim 2021 7- In colorectal cancer; NMR-monitored β-Catenin inhibition by a Quinoline derivative using Water-LOGSY technique B Mansour, MA Henen, WA Bayoumi, MA El-Sayed, MAM Massoud Journal of Molecular Structure 1246, 131151 8- Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study OA El-Khouly, MA Henen, AA Magda, MI Shabaan, SM El-Messery Bioorganic & medicinal chemistry 31, 115976 9- Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and … S Fares, KB Selim, FE Goda, MAA El-Sayed, NA AlSaif, MM Hefnawy, ... Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1), 1487-1498 2020 10- Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity MG Thabit, AS Mostafa, KB Selim, MAA Elsayed, MNA Nasr Bioorganic Chemistry 103, 104148 11- 1, 2, 3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226 HF Ashour, LA Abou-Zeid, AA Magda, KB Selim European journal of medicinal chemistry 189, 112062 12- Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition WM El-Husseiny, MAA El-Sayed, AS El-Azab, NA AlSaif, MM Alanazi, ... Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 744-758 2019 13- Design, synthesis and anticancer evaluation of new substituted thiophene-quinoline derivatives DIA Othman, KB Selim, AA Magda, AS Tantawy, Y Amen, K Shimizu, ... Bioorganic & Medicinal Chemistry 27 (19), 115026 14- Design, synthesis, and docking study of new quinoline derivatives as antitumor agents EE Nasr, AS Mostafa, MAA El‐Sayed, MAM Massoud Archiv der Pharmazie 352 (7), 1800355 15- Synthesis and biological evaluation of new 2-(4-fluorophenyl) imidazol-5-ones as anticancer agents YA Abo-Elanwar, AS Mostafa, MAA El-Sayed, MNA Nasr Journal of Applied Pharmaceutical Science 9 (5), 001-011 16- Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors MA Zeidan, AS Mostafa, RM Gomaa, LA Abou-Zeid, M El-Mesery, ... European journal of medicinal chemistry 168, 315-329 17- Cytotoxicity and molecular targeting study of novel 2-chloro-3-substituted quinoline derivatives as antitumor agents MAM Massoud, MA El-Sayed, WA Bayoumi, B Mansour Letters in Drug Design & Discovery 16 (3), 273-283 2018 18- Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking WM El-Husseiny, AA Magda, NI Abdel-Aziz, AS El-Azab, YA Asiri, ... European journal of medicinal chemistry 158, 134-143 19- Synthesis and anti-influenza activity of novel thiadiazole, oxadiazole and triazole based scaffolds SS Tawfik, AA Farahat, M A-A El-Sayed, AS Tantawy, O Bagato, MA Ali Letters in Drug Design & Discovery 15 (4), 363-374 20- Design, synthesis, and molecular modeling of heterocyclic bioisostere as potent PDE4 inhibitors AM Almatary, MA Elmorsy, WM El Husseiny, KB Selim, MAA El‐Sayed Archiv der Pharmazie 351 (3-4), 1700403 21- Total Synthesis of Eleuthoside A; Application of Rh-Catalyzed Intramolecular Cyclization of Diazonaphthoquinone DIA Othman, K Otsuka, S Takahashi, KB Selim, MA El-Sayed, AS Tantawy, ... Synlett 29 (04), 457-462 22- Cytotoxicity and molecular targeting study of novel 2-choro-3-substituted quinoline derivatives as antitumor agents WABBM Mohammed A. M. Massoud, Magda A. A El-Sayed Letters in Drug Design & Discovery 15 23- 2-Chloroquinoline-3-carbaldehydes: synthesis and reactions (2012-2017). MAM Massoud, WA Bayoumi, AA Farahat, MA El-Sayed, B Mansour ARKIVOC: Online Journal of Organic Chemistry 2018 24- Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies AS El-Azab, AAM Abdel-Aziz, LA Abou-Zeid, WM El-Husseiny, ... Journal of enzyme inhibition and medicinal chemistry 33 (1), 989-998 25- Synthesis, antitumour and antioxidant activities of novel α, β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study WM El-Husseiny, MAA El-Sayed, NI Abdel-Aziz, AS El-Azab, ER Ahmed, ... Journal of Enzyme Inhibition and Medicinal Chemistry 33 (1), 507-518 2017 26- Molecular modeling and synthesis of new heterocyclic compounds containing pyrazole as anticancer drugs FN Takla, AA Farahat, MAA El-Sayed, MNA Nasr International Journal of Organic Chemistry 7 (04), 369-388 27- Synthesis and Anti-influenza Activity of Novel Thiadiazole, Oxadiazole and Triazole Based Scaffolds MAA Samar S. Tawfik, Abdelbasset A. Farahat*, Magda A.-A El-Sayed, Atif S ... Letters in Drug Design & Discovery 14 28- Synthesis, biological evaluation and molecular modeling of novel benzofuran-N- heterocyclic hybrids as anticancer agents FEG Salma Fares, Khalid B. Selim*, Magda A. A. El-Sayed* Journal of American Science 13 (11), 65-76 2016 29- Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4 (3H)-quinazolinones AM Alaa, LA Abou-Zeid, KEH ElTahir, RR Ayyad, AA Magda, AS El-Azab European Journal of Medicinal Chemistry 121, 410-421 30- Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4 (3H) quinazolinone analogues IA Al-Suwaidan, AAM Abdel-Aziz, TZ Shawer, RR Ayyad, AM Alanazi, ... Journal of enzyme inhibition and medicinal chemistry 31 (1), 78-89 2015 31- Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: molecular modeling study SM Bayomi, HA El-Kashef, MB El-Ashmawy, MNA Nasr, MA El-Sherbeny, ... European journal of medicinal chemistry 101, 584-594 32- Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1, 3-dione, 2-hydrazonobutane-1, 3-dione and trifluoromethyl-1H-pyrazole analogues IA Al-Suwaidan, NI Abdel-Aziz, AS El-Azab, MAA El-Sayed, AM Alanazi, ... Journal of Enzyme Inhibition and Medicinal Chemistry 30 (4), 679-687 2013 33- Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues AS El-Azab, AM Alanazi, NI Abdel-Aziz, IA Al-Suwaidan, MAA El-Sayed, ... Medicinal Chemistry Research 22, 2360-2375 34- Novel benzofuran derivatives: synthesis and antitumor activity DI Othman, AMM Abdelal, MA El-Sayed, SAA El Bialy Heterocyclic Communications 19 (1), 29-35 2012 35- Synthesis and antiviral activity of new 3-methyl-1,5-diphenyl-1H-pyrazole derivatives AS Tantawy, MNA Nasr, MAA El-Sayed, SS Tawfik Medicinal Chemistry Research 21, 4139-4149 36- Computational modeling, synthesis, and antioxidant potential of novel phenylcarbamoylbenzoic acid analogs in combating oxidative stress WA Bayoumi, MA Elsayed, HN Baraka, L Abou‐zeid Archiv der Pharmazie 345 (11), 902-910 37- Synthesis of new phenylcarbamoylbenzoic acid derivatives and evaluation of their in vitro antioxidant activity WA Bayoumi, MA Elsayed Medicinal Chemistry Research 21, 1633-1640 38- Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2 AA Magda, NI Abdel-Aziz, AM Alaa, AS El-Azab, KEH ElTahir Bioorganic & medicinal chemistry 20 (10), 3306-3316 39- Synthesis and biological evaluation of new unsaturated derivatives of cyclic compounds as potent antioxidant agent A Magda, MA Massoud, AS Tantawy, MN Nasr, AEDM Barghash, ... Der Pharma Chemica 5, 1785-97 40- Synthesis and cytotoxic activity of new furanochromone derivatives MA El-Said, SR Gedara, I Abdel-aziz Journal of American Sciences 8 (12), 851-857 2011 41- Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study AA Magda, NI Abdel-Aziz, AM Alaa, AS El-Azab, YA Asiri, KEH ElTahir Bioorganic & medicinal chemistry 19 (11), 3416-3424 2010 42- Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study AS El-Azab, MA Al-Omar, AM Alaa, NI Abdel-Aziz, AA Magda, AM Aleisa, ... European journal of medicinal chemistry 45 (9), 4188-4198 2004 43- Synthesis of certain 6-(arylthio) uracils and related derivatives as potential antiviral agents AA El-Emam, MAM Massoud, ER El-Bendary, MA El-Sayed BULLETIN-KOREAN CHEMICAL SOCIETY 25 (7), 991-996 2003 44- The response of rice plant to phosphate-dissolving bacteria and Azolla under two phosphorous fertilization rates AE Magda, MA El-Latif, AA El-Masry, MA Abdel-Megid Egypt. J. Appl. Sci 18, 694-705 1984 45- Seed pretreatment with phosphorus and IAA as a method for increasing phosphate by barley plant RS Abdelaal, MA Massoud, M Elsayed Arab Journal of Nuclear Sciences and Applications 17 (1), 163-183 1979 46- Effect of soil salt content on the availability of native and applied phosphorus MA Massoud, RS Abdelaal, K Sadek, M Elsayed Arab Journal of Nuclear Sciences and Applications 17 (1), 89-104 |
Prof. Dr. Magda abd El Aziz |
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Exploring the dual effect of novel 1, 4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms, Azizah M Malebari, Hany EA Ahmed, Saleh K Ihmaid, Abdelsattar M Omar, Yosra A Muhammad, Sultan S Althagfan, Naif Aljuhani, Abdel-Aziz AA El-Sayed, Ahmed H Halawa, Heba M El-Tahir, Safaa A Turkistani, Mohammed Almaghrabi, Ahmed KB Aljohani, Ahmed M El-Agrody, Hamada S Abulkhair, Bioorganic Chemistry, 2023, https://doi.org/10.1016/j.bioorg.2022.106255 Exploring the cytotoxic effect and CDK-9 inhibition potential of novel sulfaguanidine-based azopyrazolidine-3, 5-diones and 3, 5-diaminoazopyrazoles, Ebtehal M Husseiny, Hamada S Abulkhair, Nehad M El-Dydamony, Kurls E Answer, Bioorganic Chemistry, 2023, https://doi.org/10.1016/j.bioorg.2023.106397 The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations, Arafa Musa, Saleh K Ihmaid, David L Hughes, Musa A Said, Hamada S Abulkhair, Ahmed H El-Ghorab, Mohamed A Abdelgawad, Khaled Shalaby, Mohamed E Shaker, Khalid Saad Alharbi, Nasser Hadal Alotaibi, Deborah L Kays, Laurence J Taylor, Della Grace Thomas Parambi, Sami I Alzarea, Ahmed A Al-Karmalawy, Hany EA Ahmed, Ahmed M El-Agrody, Journal of Biomolecular Structure and Dynamics, 2023, https://doi.org/10.1080/07391102.2023.2167000 A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses, Maan T Khayat, Hany EA Ahmed, Abdelsattar M Omar, Yosra A Muhammad, Khadijah A Mohammad, Azizah M Malebari, Ahdab N Khayyat, Ahmed H Halawa, Hamada S Abulkhair, Ahmed A Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S Aljahdali, Ahmed M El-Agrody, Journal of Biomolecular Structure and Dynamics, 2023, https://doi.org/10.1080/07391102.2023.2188957 Phenylpyrazolone-1, 2, 3-triazole Hybrids as Potent Antiviral Agents with Promising SARS-CoV-2 Main Protease Inhibition Potential, Arafa Musa, Hamada S Abulkhair, Ateyatallah Aljuhani, Nadjet Rezki, Mohamed A Abdelgawad, Khaled Shalaby, Ahmed H El-Ghorab, Mohamed R Aouad, Pharmaceuticals, 2023, https://doi.org/10.3390/ph16030463 In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-MPro inhibitors, Ateyatallah Aljuhani, Hany E. A. Ahmed, Saleh K. Ihmaid, Abdelsattar M. Omar, Sultan S. Althagfan, Yaser M. Alahmadi, Iqrar Ahmad, Harun Patel, Sahar Ahmed, Mohannad A. Almikhlafi, Ahmed M. El-Agrody, Mohamed F. Zayed, Safaa Abdulrahman Turkistani, Shorouk H. Abulkhair, Mohammed Almaghrabi, Samir A. Salam, Ahmed A. Al-Karmalawy & Hamada S. Abulkhair, RSC Advances, 2022,12, 26895-26907. https://doi.org/10.1039/D2RA04015H Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies, Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al‐Karmalawy, Hamada S. Abulkhair, Mokhtar R. Gomaa, Ahmed N. El-Taweel, Noura M. Abo Shama, Mohamed GabAllah, Dina B. Mahmoud, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil & Ahmed Mostafa, Scientific Reports, 2022, https://www.nature.com/articles/s41598-022-17082-6 The effect of novel synthetic semicarbazone- and thiosemicarbazone-linked 1,2,3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia, Esraa M. Othman, Eman A. Fayed, Ebtehal M.Husseiny, Hamada S. Abulkhair, Bioorganic Chemistry, 2022, https://doi.org/10.1016/j.bioorg.2022.105968 New quinoxalin-2(1H)-one-derived VEGFR-2 inhibitors: Design, synthesis, in vitro anticancer evaluations, in silico ADMET, and docking studies, Khaled El-Adl, Helmy M. Sakr, Reda G. Yousef, Ahmed B. M. Mehany, Hamada S. Abulkhair, Ibrahim H. Eissa, Archiv der Pharmazie, 2022, 202200048, https://doi.org/10.1002/ardp.202200048 Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1,2,3-triazole-chalcone conjugates, Esraa M. Othman, Eman A. Fayed, Ebtehal M. Husseiny, Hamada S. Abulkhair, Bioorganic Chemistry, 2022, https://doi.org/10.1016/j.bioorg.2022.105762 Rationale design, synthesis, cytotoxicity evaluation, and in silico mechanistic studies of novel 1,2,3-triazoles with potential anticancer activity, Esraa M. Othman, Eman A. Fayed, Ebtehal M. Husseiny, Hamada S. Abulkhair, New Journal of Chemistry, 2022, https://doi.org/10.1039/D2NJ02061K Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity, Mohamed M. Hammoud, Muhammad Khattab, Marwa Abdel-Motaal, Johan Van der Eycken, Radwan Alnajjar, Hamada S. Abulkhair & Ahmed Ali Al‐Karmalawy, Journal of Biomolecular Structure & Dynamics, 2022, https://www.tandfonline.com/doi/full/10.1080/07391102.2022.2082533 Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR-2 inhibitors, Khaled El-Adl, Mohamed K. Ibrahim, Fathalla Khedr, Hamada S. Abulkhair, Ibrahim H. Eissa, Archiv der Pharmazie, 2022, 2100278, https://doi.org/10.1002/ardp.202100278 From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity, Mohamed H. El-Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Ahmed A.Al-Karmalawy, Ebtehal M.Husseiny, Mona S. El‐Zoghbi, Hamada S. Abulkhair, Bioorganic & Medicinal Chemistry, 2021, https://doi.org/10.1016/j.bmc.2021.116266 1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity, Mohamed H. El-Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Hany E. A. Ahmed, Mona S. El‐Zoghbi, Khaled El‐Adl, Hamada S. Abulkhair, New Journal of Chemistry, 2021, https://doi.org/10.1039/D1NJ00710F. β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization, Mohammed I. A. Hamed, Khaled M. Darwish, Raya Soltane, Amani Chrouda, Ahmed Mostafa, Noura M. Abo Shama, Sameh S. Elhady, Hamada S. Abulkhair, Ahmed E. Khodir, Ayman Abo Elmaaty and Ahmed A. Al-karmalawy, RSC Advances, 2021,11, 35536-35558. https://doi.org/10.1039/D1RA04820A Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum, Ahmed A. Zaki, Mohamed M. Y. Kaddah, Hamada S. Abulkhair and Ahmed Ashour, RSC Advances, 2022,12, 2980-2991. https://doi.org/10.1039/D1RA08532H Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization, Ayman Abo Elmaaty, Mohammed I. A. Hamed, Muhammad I. Ismail, Eslam B. Elkaeed, Hamada S. Abulkhair, Muhammad Khattab, and Ahmed A. Al‐Karmalawy, Molecules, 2021, https://doi.org/10.3390/molecules26123772 N-Substituted-4-phenylphthalazin-1-amine-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies, Khaled El-Adl, Mohamed-Kamal Ibrahim, Fathalla Khedr, Hamada S. Abulkhair, Ibrahim H. Eissa, Archiv der Pharmazie, 2021, 2000219, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202000219 The antimicrobial potential and pharmacokinetic profiles of novel quinoline-based scaffolds: synthesis and in silico mechanistic studies as dual DNA gyrase and DHFR inhibitors, Mohamed H. El-Shershaby, Kamal M. El-Gamal, Ashraf H. Bayoumi, Khaled El-Adl, Mohamed Alswah, Hany E. A. Ahmed, Ahmed A. Al-Karmalamy, Hamada S. Abulkhair, New Journal of Chemistry, 2021, https:// 10.1039/D1NJ02838C Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation, Khaled El-Adl, Helmy M. Sakr, Reda G. Yousef, Ahmed B. M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A.E lSohly, Hamada S. Abulkhair, Ibrahim H.Eissa, Bioorganic Chemistry, 2021, 105105, https://doi.org/10.1016/j.bioorg.2020.105105 Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies, Amal Mahmoud, Ahmed Mostaf, Ahmed A. Al-Karmalawy, Ahmad Zidand, Hamada S. Abulkhair, Sara H. Mahmoud, Mahmoud Shehata, Mahmoud M. Elhefnawi, Mohamed A. Ali, Heliyon, 2021, https://doi.org/10.1016/j.heliyon.2021.e07962 Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies, Ahmed A. Gaber, Ahmed M. El-Morsy, Farag F. Sherbiny, Ashraf H. Bayoumi, Kamal M. El-Gamal, Khaled El-Adl, Ahmed A. Al-Karmalawy, Rogy R. Ezz Eldin, Marwa A. Saleh, Hamada S. Abulkhair, Archiv der Pharmazie, 2021, 2000219, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202100258 Phthalazine-based VEGFR-2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations, Fathalla Khedr, Mohamed-Kamal Ibrahim, Ibrahim H. Eissa, Hamada S. Abulkhair, Khaled El-Adl, Archiv der Pharmazie, 2021, 2000201, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202100201 New quinoxaline-2(1H)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations, Reda G. Yousef, Helmy M. Sakr, Ibrahim H. Eissa, Ahmed B. M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A.E lSohly, Hamada S. Abulkhair, Khaled El-Adl, New Journal of Chemistry, 2021, https://doi.org/10.1039/D1NJ02509K Design, synthesis, docking and anticancer evaluations of phthalazines as VEGFR-2 inhibitors, Khaled El-Adl, Mohamed-Kamal Ibrahim, Fathalla Khedr, Hamada S. Abulkhair, Ibrahim H. Eissa, Archiv der Pharmazie, 2021, 2000278, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202100 278 In vivo‐and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors, Hamada S. Abulkhair, Salwa Elmeligie, Adel Ghiaty, Ahmed El‐Morsy, Ashraf H. Bayoumi, Hany E. A. Ahmed, Khaled El‐Adl, Mohamed F. Zayed, Memy H. Hassan, Eman N. Akl, Mona S. El‐Zoghbi, Archiv der Pharmazie, 2021, 2000491, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202000449 Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2, 4‐dione derivatives as VEGFR‐2 inhibitors, Khaled El-Adl, Helmy Sakr, Sanadelaslam S. El‐Hddad, Abdel‐Ghany A. El‐Helby, Mohamed Nasser, Hamada S. Abulkhair, Archiv der Pharmazie, 2021, 2000491, https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202000491 Design, synthesis, docking, anticancer and in silico pharmacokinetic studies of novel 5-([4-chloro/2,4-dichloro]benzylidene)thiazolidine-2,4-dione derived VEGFR-2 inhibitors, Khaled El-Adl, Mohamed-K. Ibrahim, Fathalla Khedr, Hamada S. Abulkhair, Ibrahim H. Eissa, Archiv der Pharmazie, 2020, 2000279, https://doi.org/10.1002/ardp.202000279 Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives, Mohamed H. El-Shershaby, Kamal M. El-Gamal, Ashraf H. Bayoumi, Khaled El-Adl, Hany E. A. Ahmed, Hamada S. Abulkhair, Archiv der Pharmazie, 2020, 2000277, https://doi.org/10.1002/ardp.202000277 Novel 1,2,4‐triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies, Abdallah Turky, Farag F. Sherbiny, Ashraf H. Bayoumi, Hany E. A. Ahmed, Khaled El-Adl, Hamada S. Abulkhair, Archiv der Pharmazie, 2020, 2000170, https://doi.org/10.1002/ardp.202000170 Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies, Abdallah Turky, Ashraf H. Bayoumi, Farag F. Sherbiny, Khaled El-Adl, Hamada S. Abulkhair, Molecular Diversity, 2020, 10131, https://doi.org/10.1007/s11030-020-10131-0 Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies, Hamada S. Abulkhair, Abdallah Turky, Adel Ghiaty, Hany E. A. Ahmed, Ashraf H. Bayoumi, Bioorganic Chemistry, 2020, 103899, https://doi.org/10.1016/j.bioorg.2020.103899. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosisinductive and PCAF-inhibitory effects, Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Adel S. Azab, Alaa A.-M. Abdel-Aziz, Hamada S. Abulkhair, Bioorganic Chemistry, 2020, 104019, https://doi.org/10.1016/j.bioorg.2020.104019 Triazolophthalazine Incorporating Piperazine Derivatives: Synthesis and In Vitro Anticancer Evaluation Study, Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Hamada S. Abulkhair, Az. J. Pharm Sci . 2020, 61, 104-116. DOI: 10.21608/AJPS.2020.86020 The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase, Abdelsattar M. Omarab, SalehIhmaid, EL-Sayed E. Habib, Sultan S. Althagfan, Sahar Ahmed, Hamada S. Abulkhair, Hany E. A. Ahmed, Bioorganic Chemistry, 2020, 99, 103781, https://doi.org/10.1016/j.bioorg.2020.103781 Design, synthesis, and molecular docking studies of new [1,2,4]triazolo[4,3-a]quinoxaline derivatives as potential A2B receptor antagonists, Hany G. Ezzat, Ashraf H. Bayoumi, Farag F. Sherbiny, Ahmed M. El-Morsy, Adel Ghiaty, Mohamed Alswah & Hamada S. Abulkhair, Molecular Diversity (2020). https://doi.org/10.1007/s11030-020-10070-w Synthesis and antibacterial evaluation of a novel library of 2-(thiazol-5-yl)-1,3,4-oxadiazole derivatives against methicillin-resistant Staphylococcus aureus (MRSA), Mohamed H. Hannoun, Mohamed Hagras, Ahmed Kotb, Abdul-Aziz M. El-Attar, Hamada S. Abulkhair, Bioorganic Chemistry, 2020, 94, 103364, https://doi.org/10.1016/j.bioorg.2019.103364 Design and synthesis of new heterocyclic compounds to overcome microbial resistance, Al-Azhar Journal of Pharmaceutical Sciences, 2019, 60 (2), 14-25, https://dx.doi.org/10.21608/ajps.2019.70231 Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors, Abdel‐Ghany A. El‐Helby, Helmy Sakr, Ibrahim H. Eissa, Hamada S. Abulkhair, Ahmed A. Al‐Karmalawy, Khaled El‐Adl, Archiv der Pharmazie, 2019, 352(10). https://doi.org/10.1002/ardp.201900113 Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants, Abdel‐Ghany A. El‐Helby, Rezk R. A. Ayyad Mohamed F. Zayed, Hamada S. Abulkhair, Hazem Elkady, Khaled El‐Adl, Archiv der Pharmazie, 2019, 352(5). https://doi.org/10.1002/ardp.201800387 Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis, Islam Eid, Mohamed M. Elsebaei, Haroon Mohammad, Mohamed Hagras, Christine E. Peters, Youssef A. Hegazy, Bruce Cooper, Joe Pogliano, Kit Pogliano, Hamada S. Abulkhair, Mohamed N. Seleem, Abdelrahman S. Mayhoub, European Journal of Medicinal Chemistry, 2017, 139, 665-673. https://doi.org/10.1016/j.ejmech.2017.08.039 Rational design, synthesis, pharmacophore modeling, and docking studies for identification of novel potent DNA-PK inhibitors, Saleh Ihmaid, Hany E. A. Ahmed, Adeeb Al-Sheikh Ali, Yousery E. Sherif, Hamadeh M. Tarazi, Sayed M. Riyad, Mohamed F. Zayed, Hamada S. Abulkhair, Heba S. Rateb, Bioorganic Chemistry, 2017, 72, 234-247. https://doi.org/10.1016/j.bioorg.2017.04.014 Synthesis, characterization and in vitro antitumor evaluation of new pyrazolo[3,4-d]pyrimidine derivatives, Ahmed M. El-Morsy, Mohamed S. El-Sayed, Hamada S. Abulkhair¸ Open Journal of Medicinal Chemistry, 7, 1-17, 2017. https://doi.org/10.4236/ojmc.2017.71001 Synthesis, Biological Evaluation and Binding Studies of New Flavone Derivatives as Adenosine A2B Receptor Antagonists, Farag F. Sherbiny, Hamada S. Abulkhair, Adel Saad, Helmy Sakr, Ahmed Mustafa, Al-Azhar Journal of Pharmaceutical Sciences, 2016, 53(1), 73-89. https://dx.doi.org/10.21608/ajps.2016.6894 Molecular Docking, Synthesis and Biological Evaluation of Some Novel 2-Substituted-3-allyl-4(3H)-quinazolinone Derivatives as Anticonvulsant Agents, Hamada S. Abulkhair, Kamal M El-Gamal, Khaled El-Adl and Mohamed F Fadl, Medicinal Chemistry (Los Angeles) , 2016, 6(9), 593-603. Synthesis, characterization and antimicrobial evaluation of some novel quinoline derivatives bearing different heterocyclic moieties, Kamal M. El-Gamal, Mohamed S. Hagrs, Hamada S. Abulkhair, Bulletin of Faculty of Pharmacy, Cairo University, 2016, 54(2), 263–273. https://doi.org/10.1016/j.bfopcu.2016.08.002 Synthesis and preliminary antimicrobial evaluation of some new 6-methoxyquinoline-3-carbonitrile derivatives, Mohamed Hagrs, Ashraf H. Bayoumi, Kamal M. El-Gamal, Abdelrahman S. Mayhoub, Hamada S. Abulkhair, Beni-suef University Journal of Basic and Applied Sciences, 4, 2015, 338–345. https://doi.org/10.1016/j.bjbas.2015.09.001 Synthesis and Evaluation of Some New (1,2,4) Triazolo(4,3-a)Quinoxalin-4(5H)-one Derivatives as AMPA Receptor Antagonists, Hamada S. Abulkhair, Salwa Elmeligie, Ashraf Bayoumi, Adel Ghiaty, Ahmed El-Morsy, and Memy H. Hassan, Journal of Heterocyclic Chemistry, 50, 2013, 1202-1208. https://doi.org/10.1002/jhet.714 Synthesis and evaluation of some new 1,2,4-triazolo(4,3-a) quinoxalin-4-5H-one derivatives as AMPA receptor antagonists, Ashraf Bayoumi, Adel Ghiaty, Ahmed El-Morsy, Hamada S. Abulkhair, Memy H. Hassan, Salwa Elmeligie, Bulletin of Faculty of Pharmacy, Cairo University, 50, 2012, 141–146. https://doi.org/10.1016/j.bfopcu.2012.05.002 |
Prof. Dr. Hamada S. Abulkhair |
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Design, synthesis, and molecular modeling of heterocyclic bioisostere as potent PDE4 inhibitors Aya M. Almatary, Mohammad A. Elmorsy, Walaa M. El Husseiny, Khalid B. Selim, Magda A.-A. El-Saye 2018 Nitroimidazole-sulfonamides as carbonic anhydrase IX and XII inhibitors targeting tumor hypoxia: Design, synthesis, molecular docking and molecular dynamics simulation Aya M Almatary, Walaa M El Husseiny, Khalid B Selim, Hassan MH Eisa Synthesis and biological evaluation of O4′-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents AHE Hassan, Y Choi, R Kim, HJ Kim, AM Almatary, SM El-Sayed, Y Lee, ...Bioorganic & Medicinal Chemistry, 117826 Identification of Benzothiazoles Bearing 1, 3, 4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study WA Ewes, SS Tawfik, AM Almatary, M Ahmad Bhat, HW El-Shafey, ...Molecules 29 (13), 3186 2022 |
Lecturer Aya EL-Matary |
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Identification of novel sulfathiazole‐triazolo‐chalcone hybrids as VEGFR‐2/EGFR dual inhibitors with antiangiogenic activity and apoptotic induction
MA Zeidan, DIA Othman, FE Goda, AS MostafaArchiv der Pharmazie 357 (3), 2300320 Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors. Mohamed A. Zeidan, Amany S. Mostafa, Rania M. Gomaa, Laila A. Abou-Zeid, Mohamed El-mesery, Magda A- A. El-Sayed, Khalid B. Selim. European Journal of Medicinal Chemistry. 2019 Thiazole ring-cleavage; Versatile products obtained in the course of synthesis of certain sulfonamide derivatives. Mohamed A. Zeidan, Dina I. Othman, Fatma E. Goda, Amany S. Mostafa. Journal of Molecular Structure. 2023 |
Lecturer Mohamed Zeidan |
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Benzimidazole based hybrids as privileged candidates for topoII inhibition: Design, synthesis and molecular modeling studies
Nawareg, N.A., Mostafa, A.S., El-Messery, S.M., Nasr, M.N.A Journal of Molecular StructureThis link is disabled., 2024, 1298, 137020 |
TA. Nariman Abd El Aziz Nawareg |
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