التخصص العلمي علم الأدوية
أ. د. ماجدة نصر
نائب رئيس الجامعة وعميد الكلية
نرحب بكل من يساهم في بناء مستقبل وطننا لمساعدته على أن يأخذ مكانة مميزة بين الأمم.
الأبحاث المنشورة لعلم الأدوية
الأبحاث الحديثة المنشورة في المؤتمرات والمجلات المحلية والعالمية
2018 - 2020
| # | عنوان البحث | المؤلف | جهة النشر |
|---|---|---|---|
| 1 | Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation | Khaleel, Sahar A; Raslan, Nahed A; Alzokaky, Amany A; Ewees, Mohamed G; Ashour, Ahmed A; Abdel-Hamied, Hala E; Abd-Allah, Adel R; | Chemico-biological interactions |
| 2 | C‐phycocyanin protects against ethanol‐induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF‐κB pathway | Alzokaky,Amany Abdel‐mageed; Abdelkader, Eman M; El‐Dessouki, Ahmed M; Khaleel, Sahar A; Raslan, Nahed A; | Basic & Clinical Pharmacology & Toxicology |
| 3 | Targeting the proline-rich tyrosine kinase 2/Mitochondrial calcium uniporter pathway, ruthenium red, and nimodipine alone and in combination evoked neuroprotective effect in experimentally induced brain stroke in rats | Amany, A Alzokaky; | Op Acc J Bio Sci & Res |
| 4 | Saxagliptin mitigates airway inflammation in a mouse model of acute asthma via modulation of NF-kB and TLR4 | Helal, Manar G; Megahed, Nermeen A; Abd Elhameed, Ahmed G; | Life sciences |
| 5 | Flavocoxid attenuates airway inflammation in ovalbumin-induced mouse asthma model | RR Abdеlaziz, M kh Еlmahdy, GM Suddеk | Chemico-Biological Interactions |
| 6 | Potential anti-inflammatory effect of dapagliflozin in HCHF diet-induced fatty liver degeneration through inhibition of TNF-α, IL-1β, and IL-18 in rat liver | MK ElMahdy, MG Helal, TM Ebrahim | International Immunopharmacology |
| 7 | Impact of interferon β-1b, interferon β-1a and fingolimod therapies on serum interleukins-22, 32α and 34 concentrations in patients with relapsing-remitting multiple sclerosis | MA Abdel-Dayem, ME Shaker, NM Gameil | Journal of Neuroimmunology |
| 8 | Investigating Pirfenidone and Vitamin D for Targeting Cardiac and Renal Fibrotic Pathways in Experimentally-Induced Animal | Model S Antar, MF El-Azab, R Hazem, M Saleh | Records of Pharmaceutical and Biomedical Sciences 3 (1), 11-16 |
| 9 | Pirfenidone and vitamin D ameliorate cardiac fibrosis induced by doxorubicin in Ehrlich ascites carcinoma bearing mice: modulation of monocyte chemoattractant protein-1 and Jun … | MA Saleh, SA Antar, RM Hazem, MF El-Azab | Pharmaceuticals 13 (11), 348 |
الأبحاث الحديثة المنشورة في المؤتمرات والمجلات المحلية والعالمية
2021 - 2022
| # | عنوان البحث | المؤلف | جهة النشر |
|---|---|---|---|
| 1 | Telmisartan inhibits the non-canonical TGF-β/JAK2/STAT3 signaling pathway and prevents carbon tetrachloride-induced liver fibrosis in rats | Fouad, Lamiaa; Alzokaky, Amany; Abdelbaky, Nayira; Ahmed, Kawkab; | Azhar International Journal of Pharmaceutical and Medical Sciences |
| 2 | Comparative study on the influence of L carnitine and/or fenofibrate against streptozotocin induced diabetic nephropathy: role of TGF-β1/Smad Signaling Pathway. | Ahmed, Marwa A; Alzokaky, Amany A; Raslan, Nahed A; Abdelbaky, Nayira A; | Azhar International Journal of Pharmaceutical and Medical Sciences |
| 3 | Mangifera indica Leaves Extracts Mitigate Experimentally Induced Oxidative Stress and Iron-Overload via Iron Chelation and Modulation of HO-1, Nrf2, and MMP-9 | Abd Elhameed, Ahmed; Suliman, Sara; Elsbaey, Marwa; Elnaggar, Mai; Badria, Farid; | Journal of Advanced Pharmacy Research |
| 4 | Formulation and optimization of nanospanlastics for improving the bioavailability of green tea epigallocatechin gallate | Mazyed, Eman A; Helal, Doaa A; Elkhoudary, Mahmoud M; Abd Elhameed, Ahmed G; Yasser, Mohamed; | Pharmaceuticals |
| 5 | Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk | Helal, Manar G; Abd Elhameed, Ahmed G; | Environmental Science and Pollution Research |
| 6 | Krill oil and low-dose aspirin combination mitigates experimentally induced silicosis in rats: role of NF-κB/TGF-β1/MMP-9 pathway | Abd Elhameed, Ahmed G; | Environmental Science and Pollution Research |
| 7 | Lactoferrin Ameliorates Azithromycin-induced Cardiac Injury: Insight into Oxidative Stress/TLR4/NF-κB Pathway | Helal, Manar; Shawky, Mohamed; Elhusseiny, Shady; Abd Elhameed, Ahmed; | Journal of Advanced Pharmacy Research |
| 8 | Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: A novel suppressive impact on Wnt/Hedgehog/Notch1 signaling | Abd Elhameed, Ahmed G; Helal, Manar G; Said, Eman; Salem, Hatem A; | Environmental Toxicology and Pharmacology |
| 9 | Novel potent and selective DPP-4 inhibitors: design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids | Mourad, Ahmed AE; Khodir, Ahmed E; Saber, Sameh; Mourad, Mai AE; | Pharmaceuticals |
| 10 | The therapeutic role of Lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress | El-Baz, Ahmed M; Shata, Ahmed; Hassan, Hanan M; El-Sokkary, Mohamed MA; Khodir, Ahmed E; | International Immunopharmacology |
| 11 | A novel combination therapy using rosuvastatin and lactobacillus combats dextran sodium sulfate-induced colitis in high-fat diet-fed rats by targeting the TXNIP/NLRP3 interaction and influencing gut microbiome composition | Saber, Sameh; Abd El-Fattah, Eslam E; Yahya, Galal; Gobba, Naglaa A; Maghmomeh, Abdalkareem Omar; Khodir, Ahmed E; Mourad, Ahmed AE; Saad, Ahmed S; Mohammed, Hager G; Nouh, Nehal A; | Pharmaceuticals ,MDPI |
| 12 | Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into tlr4/nf-kb/caspase signalling modulation | El-Sherbiny, Mohamed; Eisa, Nada H; El-Magd, Nada F Abo; Elsherbiny, Nehal M; Said, Eman; Khodir, Ahmed E; | Environmental Toxicology and Pharmacology |
| 13 | A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1/JNK1 pathway | Antar, Samar A; ElMahdy, Mohamed Kh; Khodir, Ahmed E; | International Immunopharmacology |
| 14 | β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization | Hamed, Mohammed IA; Darwish, Khaled M; Soltane, Raya; Chrouda, Amani; Mostafa, Ahmed; Shama, Noura M Abo; Elhady, Sameh S; Abulkhair, Hamada S; Khodir, Ahmed E; Elmaaty, Ayman Abo; | RSC advances |
| 15 | Telmisartan inhibits the non-canonical TGF-β/JAK2/STAT3 signaling pathway and prevents carbon tetrachloride-induced liver fibrosis in rats | Fouad, Lamiaa; Alzokaky, Amany; Abdelbaky, Nayira; Ahmed, Kawkab; | Azhar International Journal of Pharmaceutical and Medical Sciences |
| 16 | Comparative study on the influence of L carnitine and/or fenofibrate against streptozotocin induced diabetic nephropathy: role of TGF-β1/Smad Signaling Pathway. | Ahmed, Marwa A; Alzokaky, Amany A; Raslan, Nahed A; Abdelbaky, Nayira A; | Azhar International Journal of Pharmaceutical and Medical Sciences |
| 17 | A novel role of pirfenidone in attenuation acetic acid induced ulcerative colitis by modulation of TGF-β1/JNK1 pathway | SA Antar, MK ElMahdy, AE Khodir | International Immunopharmacology |
| 18 | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB … | MK ElMahdy, SA Antar, EK Elmahallawy, W Abdo, HHA Hijazy, ... | Biomedicines |
| 19 | MK ElMahdy, MO Zaki, AA Al-Karmalawy, W Abdo, SM Alnasser, SA Antar | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases … | Life Sciences |
| 20 | Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study | MK Еlmahdy, RR Abdelaziz, HS Elmahdi, GM Suddеk | Autoimmunity |
| 21 | Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues | SG El-Sawah, F Althobaiti, A Aldhahrani, E Fayad, MA Abdel-Dayem, ... | Biocell 45 (6), 1561 |
| 22 | Novel protection by omega-3-FAs against strychnine-induced tonic-convulsion in mice: synergy with carbamazepine | AM El-Mowafy, MA Abdel-Dayem | Journal of Food Science and Nutrition Research 4 (3), 227-239 |
| 23 | Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats , ... | SA Antar, W Abdo, RS Taha, AE Farage, LE El-Moselhy, ME Amer | Life sciences |
| 24 | Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor ... | RM Hazem, SA Antar, YK Nafea, AA Al-Karmalawy, MA Saleh, | Life Sciences |
| 25 | A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways | MF El-Azab, AA Al-Karmalawy, SA Antar, PA Hanna, KM Tawfik | Life Sciences 303, 120691 11 |
| 26 | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB … | MK ElMahdy, SA Antar, EK Elmahallawy, W Abdo, HHA Hijazy, ... | Biomedicines 10 (1), 40 9 |
| 27 | Protective effects of mirazid on gentamicin-induced nephrotoxicity in rats through antioxidant, anti-inflammatory, JNK1/iNOS, and apoptotic pathways; novel mechanistic insights , ... | S Antar, AA Al-Karmalawy, A Mourad, M Mourad, M Elbadry, S Saber | Pharmaceutical Sciences 28 (4), 525-540 |
| 28 | Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo | AA Al-Karmalawy, MS Nafie, MA Shaldam, AA Elmaaty, SA Antar, . | Journal of Medicinal Chemistry |
| 29 | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases … | MK ElMahdy, MO Zaki, AA Al-Karmalawy, W Abdo, SM Alnasser, SA Antar | Life Sciences 311, 121184 |
| 30 | Etanercept Mitigates Cadmium Chloride-induced Testicular Damage in Rats" An Insight into Autophagy, Apoptosis, Oxidative Stress and Inflammation" | SA Antar, MA El-Gammal, RM Hazem, YM Moustafa | Environmental Science and Pollution Research 29 (19), 28194-28207 |
| 31 | Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats | ME Youssef, MF El-Azab, MA Abdel-Dayem, G Yahya, IS Alanazi, S Saber | Environmental Science and Pollution Research, 1-10 |
| 32 | Novel protection by Omega-3-FAs (DHA or EPA) against carbamazepine's liver-injury: differential suppression of oxidative-stress and inflammatory markers, and the influence on … | AM El-Mowafy, AA Abdel-Aziz, MA Abdel-Dayem | Clinical Nutrition Open Science 42, 14-26 |
| 33 | Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreatic β-cells auto-immunity and apoptosis in rats with T1DM induced model | SG El-Sawah, F Althobaiti, HM Rashwan, A Aldhahrani, MA Abdel-Dayem, ... | Biocell 46 (3), 745 |
| 34 | Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy | Mennatallah O; Zaki, Elshe Mohamed; Azab, Samar S;rbiny, Doaa A; Salama, | Biocell 46 (3), 745 |
الأبحاث الحديثة المنشورة في المؤتمرات والمجلات المحلية والعالمية
2022 - 2023
| # | عنوان البحث | المؤلف | جهة النشر |
|---|---|---|---|
| 1 | Berberine-loaded nanostructured lipid carriers mitigate warm hepatic ischemia/reperfusion-induced lesion through modulation of HMGB1/TLR4/NF-κB signaling and autophagy | Gendy, Abdallah M; Elnagar, Mohamed R; Allam, Mona M; Mousa, Mohamed R; Khodir, Ahmed E; El-Haddad, Alaadin E; Elnahas, Osama S; Fayez, Sahar M; El-Mancy, Shereen S; | Biomedicine & Pharmacotherapy |
| 2 | Isolation of cytotoxic active compounds from Reichardia tingitana with investigation of apoptosis mechanistic induction: In silico, in vitro, and SAR studies | Zaki, Ahmed A; Al‐Karmalawy, Ahmed A; Khodir, Ahmed E; El-Amier, Yasser A; Ashour, Ahmed; | South African Journal of Botany |
| 3 | A Novel Role of Dapagliflozin in Mitigation of Acetic Acid-Induced Ulcerative Colitis by Modulation of Monocyte Chemoattractant Protein 1 (MCP-1)/Nuclear Factor-Kappa B (NF-κB)/Interleukin-18 (IL-18) | ElMahdy, Mohamed Kh; Antar, Samar A; Elmahallawy, Ehab Kotb; Abdo, Walied; Hijazy, Hayfa Hussin Ali; Albrakati, Ashraf; Khodir, Ahmed E; | Biomedicines |
| 4 | COVID-19 Pandemic: current Challenges and future Perspectives | Saber, Sameh; Khodir, Ahmed E; Maghmomeh, Abdalkareem Omar; Nouh, Nehal A; El-Baz, Ahmed M; | Research Journal of Pharmacy and Technology (RJPT) |
| 5 | Protective Effects of Mirazid on Gentamicin-induced Nephrotoxicity in Rats through Antioxidant, Anti-inflammatory, JNK1/iNOS, and Apoptotic Pathways; Novel Mechanistic Insights | Antar, Samar A; Al-Karmalawy, Ahmed A; Mourad, Ahmed AE; Mourad, Magda; MennaallahElbadry, Sameh Saber; Khodir, Ahmed E; | Pharmaceutical Sciences |
| 6 | Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: A new challenge for unmet therapeutic needs | Saber, Sameh; Nasr, Mohamed; Kaddah, Mohamed MY; Mostafa-Hedeab, Gomaa; Cavalu, Simona; Mourad, Ahmed AE; Gaafar, Ahmed Gaafar Ahmed; Zaghlool, Sameh S; Saleh, Safaa; Hafez, Mohamed M; | Biomedicine & Pharmacotherapy |
| 7 | A novel therapeutic combination of dapagliflozin, Lactobacillus and crocin attenuates diabetic cardiomyopathy in rats: Role of oxidative stress, gut microbiota, and PPARγ activation | Khalaf, Eman M; Hassan, Hanan M; El-Baz, Ahmed M; Shata, Ahmed; Khodir, Ahmed E; Yousef, Mahmoud E; Elgharabawy, Rehab Mohamed; Nouh, Nehal A; Saleh, Safaa; Bin-Meferij, Mashael M; | European Journal of Pharmacology |
| 8 | Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho [2′, 3′: 4, 5] thiazolo [3, 2-a] pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity | Mourad, Mai AE; Abo Elmaaty, Ayman; Zaki, Islam; Mourad, Ahmed AE; Hofni, Amal; Khodir, Ahmed E; Aboubakr, Esam M; Elkamhawy, Ahmed; Roh, Eun Joo; Al-Karmalawy, Ahmed A; | Journal of Enzyme Inhibition and Medicinal Chemistry |
| 9 | Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway | Aljohani, Heba; Khodier, Ahmed E; Al-Gayyar, Mohammed M; | Cureus |
| 10 | Etanercept Mitigates Cadmium Chloride-induced Testicular Damage in Rats" An Insight into Autophagy, Apoptosis, Oxidative Stress and | SA Antar, MA El-Gammal, RM Hazem, YM Moustafa | Inflammation" Environmental Science and Pollution Research 29 (19), 28194-28207 |
| 11 | Mechanisms of Cadmium-Induced Testicular Damage | MA El Gammal, R Hazem, Y Moustafa | Biomedical Sciences 6 (3), 28-33 |
| 12 | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation | SA Antar, NA Ashour, ME Marawan, AA Al-Karmalawy | International Journal of Molecular Sciences 24 (4), 4004 |
| 13 | Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats | AE Farage, W Abdo, A Osman, MA Abdel-Kareem, ZH Hakami | Life Sciences 322, 121688 |
| 14 | Modulatory Role of Autophagy in Metformin Therapeutic Activity toward Doxorubicin-Induced Nephrotoxicity | SA Antar, M Abd-Elsalam, W Abdo, A Abdeen, M Abdo, L Fericean | Toxics 11 (3), 273 |
| 15 | ElMahdy, Mohamed Kh; Zaki, Mennatallah O; Al-Karmalawy, Ahmed A; Abdo, Walied; Alnasser, Sulaiman Mohammed; Antar, Samar A; | Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways | Life Sciences |
| 16 | Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling | Zaki, Mennatallah O; El-Desouky, S; Elsherbiny, Doaa A; Salama, Mohamed; Azab, Samar S; | Inflammopharmacology |
| 17 | Evaluation of andbeta; Amyloids and Tau Protein Biomarkers for Alzheimerandrsquo; s Disease in Serum of Alzheimer Patients | Zaki, Mennatallah O; El-Sherifi, Saad Shawki; Abou Elmaaty, Ali Ahmed; Zakaria, Amr Y; Zidan, Abdelrheem M; Mahmoud, Abdullrahman M; Ali, Omar Sh; …… Marwa A Abdel-Dayem | Clinical Schizophrenia & Related Psychoses |
| 18 | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation. | Antar SA, Ashour NA, Marawan ME, Al-Karmalawy AA. | International Journal of Molecular Sciences. 2023;24:4004. |
الأبحاث الحديثة المنشورة في المؤتمرات والمجلات المحلية والعالمية
2023 - 2024
| # | عنوان البحث | المؤلف | جهة النشر |
|---|---|---|---|
| 1 | A randomized placebo-controlled, double-blind study to investigate the effect of a high oral loading dose of cholecalciferol in non-alcoholic fatty liver disease patients, new insights on serum STAT-3 and hepassocin | S.J. Alarfaj, M.M. Bahaa, H.A. Yassin, E. El-Khateeb, F.A. Kotkata, M.A. El-Gammal, | European Review for Medical & Pharmacological Sciences. 2023 |
| 2 | Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway | Heba Aljohani,1 Ahmed E Khodier,2 and Mohammed M Al-Gayyar | Cureus. 2023 May; 15(5): e39789. |
| 3 | Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways | Samar A Antar, Ahmed Ashour, Walied Abdo, Ahmed E Khodir, Asmaa E Sherif, Longxin Qiu, Ahmed A Zaki | 11 Jan 2024 |
| 4 | Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives | Osama Mohammed , Sameh Saber b, Mustafa Ahmed Abdel-Reheim ...... Amany A. Alzokaky | Toxicology and Applied Pharmacology Volume 486, May 2024, 116943 |
| 5 | Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice | Amany A. Alzokaky, Ahmed A. Al-Karmalawy , Mohamed A. Saleh, Walied Abdo, ......, Samar A. Antar | Life Sciences Volume 316, 1 March 2023, 121390 |
| 6 | Modulatory Role of Autophagy in Metformin Therapeutic Activity toward Doxorubicin-Induced Nephrotoxicity | SA Antar, M Abd-Elsalam, W Abdo, A Abdeen, M Abdo, L Fericean, ..., A Alzokaky | Toxics 11 (3), 273 |
| 7 | Piracetam mitigates nephrotoxicity induced by cisplatin via the AMPK-mediated PI3K/Akt and MAPK/JNK/ERK signaling pathways | Ahmed M. El-Dessouki, Amany A. Alzokaky, Nahed A Raslan, Samar Ibrahim, Lamiaa A. Salama, Eman H. Yousef | International Immunopharmacology Volume 137, 20 August 2024, 112511 |
| 8 | Mechanistic insight into the hepatoprotective effect of Moringa oleifera Lam leaf extract and telmisartan against carbon tetrachloride-induced liver fibrosis: plausible roles of TGF-β1/SMAD3/SMAD7 and HDAC2/NF-κB/PPARγ pathways | Baky, N.A.A., …, Alzokaky, A.A. | Drug and Chemical Toxicology, 2024 |
| 9 | Association of CTLA-4 rs733618 and rs4553808 Gene Variants with Psoriasis Vulgaris in Egyptian Population | Menna M. Eldawoudy1,4*, Dalia Shaalan2, Maivel H. Ghattas3, Dina M. Abo-Elmatty4, Eman T. Mehanna | Archives of Dermatological Research.2024 |
| 10 | Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation | Samar A. Antar Nada A. Ashour Mohamed E. Marawan Ahmed A. Al-Karmalawy | Int. J. Mol. Sci. 2023, 24(4), 4004; |
| 11 | Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity | Mai AE Mourad, Ayman Abo Elmaaty, Islam Zaki, Ahmed AE Mourad, Amal Hofni, Ahmed E Khodir, Esam M Aboubakr, Ahmed Elkamhawy, Eun Joo Roh, Ahmed A Al-Karmalawy | Journal of Enzyme Inhibition and Medicinal Chemistry 2023 |
| 12 | Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice | Mohamed A Saleh, Samar A Antar, Walied Abdo, Ahmed Ashour, Ahmed A Zaki | Journal of Environmental Science and Pollution Research |
| 13 | Betulin prevents high fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress and upregulating Nrf2 and SIRT1 in rats | Amira E Farage, Walied Abdo, Amira Osman, Mona A Abdel-Kareem, Zaki H Hakami, Ahmad Alsulimani, Albandari Bin-Ammar, Ashwag S Alanazi, Bader Alsuwayt, Mohammed M Alanazi, Samar A Antar, Emadeldin M Kamel, Ayman M Mahmoud | Journal of Life Sciences |
| 14 | A comprehensive overview of organ inflammatory responses: genesis, possible mechanisms, and mediators of inflammation | Samar A Antar, Ayman M Mahmoud, Walied Abdo, Cherry Gad, Ahmed A Al-Karmalawy | Pharmaceutical Sciences |
| 15 | An Overview of the Mechanisms of Cadmium-induced Toxicity in the Male Reproductive System | Samar A Antar, Aymen Halouani, Cherry Gad, Ahmed Ali Al-Karmalawy | Pharmaceutical Sciences |
| 16 | Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments | Samar A Antar, Nada A Ashour, Marwa Sharaky, Muhammad Khattab, Naira A Ashour, | Biomedicine & Pharmacotherapy |
| 17 | Examining the contribution of Notch signaling to lung disease development | Samar A Antar, Mohamed Kh ElMahdy, Ahmed G Darwish | Naunyn-Schmiedeberg's Archives of Pharmacology |
| 18 | Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice | Samar A Antar, Walied Abdo, Azza I Helal, Maisa Siddiq Abduh, Zaki H Hakami, Mohamed Kh ElMahdy | Life Sciences |
| 19 | Anti-tumor effects of Soyasaponin IV as a natural product in Ehrlich ascites carcinoma bearing mice: modulation of monocyte vascular endothelial growth factor (VEFG) and nuclear factor kappa B (NF-κB) pathways | Samar A Antar, Ahmed Ashour, Walied Abdo, Ahmed E Khodir, Asmaa E Sherif, | Arab Journal of Basic and Applied Sciences |
| 20 | Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice | Mahmoud E Youssef, Simona Cavalu, Alexandru Madalin Hasan, Galal Yahya, Marwa A Abd-Eldayem, Sameh Saber | International Journal of Molecular Sciences |
| 21 | Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control | Mahmoud E Youssef, Galal Yahya, Mihaela Simona Popoviciu, Simona Cavalu, Marwa A Abd-Eldayem, Sameh Saber | International Journal of Molecular Sciences |
| 22 | Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat mode | Simona Cavalu, Sameh Saber, Rasha Elmowafy, Nesreen Elsayed Morsy, Samar Ibrahim, Mahmoud Said Ibrahim Abdeldaiem, Mervat Samy, Marwa A Abd-Eldayem, Ahmed Shata, Rehab Mohamed Elgharabaw | Biomedicine & Pharmacotherapy |
| 23 | Association of HOTAIR gene rs920778 (C > T) and rs4759314 (A > G) polymorphism with breast cancer in Egyptian women | Mohammad M Tarabay, Rehab Elmougy, Marwa Ahmed Abdel-Dayem, | Molecular Biology Reports |
| 24 | Promising Experimental Anti-SARS-CoV-2 Agent “SLL-0197800”: The Prospective Universal Inhibitory Properties against the Coming Versions of the Coronavirus | Amgad M Rabie, Marwa A Abdel-Dayem, Mohnad Abdalla | ACS omega |
المشاريع البحثية لتخصص الادوية لقسم الأدوية و الكيمياء الحيوية بكلية الصيدلة جامعة حورس
2020 - 2021
| مشروع البحث | تحت إشراف |
|---|---|
| "Mechanistic Pathways Includedin Pathogenesis of Brain Stroke | Ass. Prof. Dr.Amany Alzokaky |
| Mechanistic Pathways Related to Nephrotoxicity | Ass. Prof. Dr.Amany Alzokaky |
| Hepatocellular Carcinoma ; pathogenesis & Advanced Therapeutic strategie | Ass. Prof. Dr. Ahmed Gamal |
| Advanced Therapeutic strategies in Treatment of Ulcerative Colitis | Ass. Prof. Dr. Ahmed Gamal |
| latrogenic Diseases | Lecturer of pharmacology Dr. Marwa Ahmed |
| Risk Factors and Mortality Rates among Patients with covid - 19 | Lecturer of pharmacology Dr. Marwa Ahmed |
| Pharmacological Treatment of covid -19 | Ass. Prof. Dr. Ahmed Esam |
| Anti - inflammatoryeffect of Apitherapyproducts | Ass. Prof. Dr. Ahmed Esam |
| Covid 19 in high riskchronic diseased patients and pregnant woman : Pathophysiology , available drug treatment and the most suitable protocol regiman in each group | Lecturer of pharmacology Dr. Mohamed khalil El - Mahdy |
المشاريع البحثية لتخصص الادوية لقسم الأدوية و الكيمياء الحيوية بكلية الصيدلة جامعة حورس
2021 - 2022
| مشروع البحث | تحت إشراف |
|---|---|
| The role of antioxidants in the Protection from gastric ulcer via NRf2 Pathway | Ass. Prof. Dr. Amany Alzokaky |
| The Protective effect of Natural Antioxidants againstGrastric uicer induced in Rats | Ass. Prof. Dr. Amany Alzokaky |
| Theraputic Advances for Management of kindey injury | Ass. Prof. Dr. Ahmed Gamal |
| The Emerging role of dipeptidyl Peptidase - 4 inhibitors in management of human carcinogenesis | Ass. Prof. Dr. Ahmed Gamal |
| SGLT2 inhibitors: novel mechanisms of cardiovascular benefits beyond glycaemic control | Lecturer of pharmacology Dr. Marwa Abd Eldayeem |
| Iatrogenic Diseases | Lecturer of pharmacology Dr. Marwa Ahmed |
| Investigation the effect of Mebeverine on Doxorubicin- Induced kidney damage | Lecturer of pharmacology Dr. Samar Ahmed Anter |
| Curative effect of nifuroxazida on doxorubicin induced nephrotoxicity | Ass. Prof. Dr. Ahmed Esam |
| curative effect of mebeverine on doxorubicin induced Hapatotoxicity in mice | Ass. Prof. Dr. Ahmed Esam |
| Effect of inhaled unfractionated heparin on airway inflammation in ovalbumin inducedasthma in mice | Lecturer of pharmacology Dr. Mohamed khalil El - Mahdy |
المشاريع البحثية لتخصص الادوية لقسم الأدوية و الكيمياء الحيوية بكلية الصيدلة جامعة حورس
2022 - 2023
| مشروع البحث | تحت إشراف |
|---|---|
| Empagliflozin ameliorates acute hepaticinjury and nephrotoxicity induced bccL4 in mice | Ass. Prof. Dr. Amany Alzokaky |
| The Possible Protective Effect of Spirulina Maxima on nephrotoxicity and acute liver injury Induced by CC14 in Mice | Ass. Prof. Dr. Amany Alzokaky |
| Cardioprotective and Antioxidant Effect of Vardenafil on Doxorubicin-Induced Cardiomyopathy | Ass. Prof. Dr.Ahmed Gamal Helal |
| Management of Neuropathic Pain | Ass. Prof. Dr.Ahmed Gamal Helal |
| Possible Protective Effect Of Atorvastatin On Cisplatin Inducing Brain Damage In Rats | Ass. Prof. Dr.Ahmed Esam Khodir |
| Possible Protective Effect Of Coenzyme Q 10 On Cisplatin Inducing Brain Damage In Rats | Ass. Prof. Dr.Ahmed Esam Khodir |
| Diabetes mellitus: Symptoms, Classification, and Complications | Lecturer of pharmacology Dr.Samar Anter |
| Fibrosis: from mechanisms to medicines | Lecturer of pharmacology Dr.Samar Anter |
| Diabetic Complications on Cardiovascular System and nervous System : Pathophysiology and Most appropriate Treatment | Lecturer of pharmacology Dr. Mohamed Khalil |
| Effect of Dapagliflozin on bleomycin-induced Iung fibrosis in mice : Prevention and Treatment | Lecturer of pharmacology Dr. Mohamed Khalil |
